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Important Therapeutic Target For Breast Cancer: Newly Appreciated Membrane Estrogen Receptor
New research at Rhode Island Hospital has uncovered the biological effects of a novel membrane estrogen receptor, a finding that has potential implications for hormonal therapy for breast cancer. The study is published in the July edition of the journal Molecular Endocrinology. This new study by Edward Filardo, MD, and his research team further supports earlier published work by the group that linked the transmembrane receptor, GPR30/GPER-1, to specific estrogen binding, rapid estrogen signaling and breast cancer metastasis. "What is exciting about this new work," says Filardo, "is that it provides some insight into the influence of GPR30 at the cellular level. It shows that estrogen action through GPR30 allows for breast tumor cell survival, and not breast tumor cell proliferation." Prior studies by Filardo"s group showed that estrogen acts through GPR30 to promote the rapid release of preformed growth factors that are tethered to the surface of breast cancer cells. Their latest study was conducted in an effort to better understand the mechanism by which GPR30 triggered the release of epidermal growth factor (EGF) polypeptides from the surface of breast cancer cells.

Study Finds Autistics Better At Problem-Solving
Autistics are up to 40 percent faster at problem-solving than non-autistics, according to a new Universitçİ de Montrçİal and Harvard University study published in the journal Human Brain Mapping. As part of the investigation, participants were asked to complete patterns in the Raven"s Standard Progressive Matrices (RSPM) - test that measures hypothesis-testing, problem-solving and learning skills.
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A Canada-Wide Technology Platform For Mapping The Human Interactome
On June 18, the Canada Foundation for Innovation (CFI) announced the award of $9.16 million for the creation of a national technology platform aimed at mapping the human interactome. This national platform, headed by Dr. Benoit Coulombe from the Institut de recherches cliniques de Montrçİal (IRCM), will not only provide Canadian researchers with new state-of-the-art equipment in proteomics, functional genomics and bioinformatics, but also bring together integrated infrastructure for deciphering the human interactome an expertise that, until now, has been spread in 12 universities across Canada.
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Briefing To Examine U.S. Strategy For Combating Malaria Around The World

The Kaiser Family Foundation will hold a briefing on June 17 to examine the U.S. government"s role in addressing malaria, including its strategic options for reducing the impact of the disease and the current status of the development of the comprehensive malaria strategy. The discussion will touch on issues such as: What will the U.S. malaria response look like over the next five years? What strategies are most likely to prove effective? How will the U.S. efforts fit into the broader global response to malaria? Moderated by Kaiser Vice President Jen Kates, the briefing will include Rear Adm. Tim Ziemer, the U.S. malaria coordinator; Sir Richard Feachem, professor of global health at the University of California, San Francisco and the University of California, Berkeley and director of the Global Health Group at University of California, San Francisco; David Brandling-Bennett, deputy director, malaria in the Global Health Program at the Bill & Melinda Gates Foundation; Natasha Bilimoria, executive director of Friends of the Global Fight Against AIDS, Tuberculosis and Malaria; and Mark Green, managing director of the Malaria Policy Center. WHEN: Wednesday, June 17, 2009, 9:30 a.m. to 11 a.m. ET (Registration and breakfast at 9 a.m.) WHERE: Barbara Jordan Conference Center (Kaiser Family Foundation Office) 1330 G Street, NW, Washington, DC (one block west of Metro Center) RSVP: Please RSVP to Tiffany Ford Fields or call 202-347-5270. CONTACT: For further information, please email Craig Palosky or call 202-347-5270. WEBCAST: For those who cannot attend in person, an archived webcast of the briefing will be available later that day at www.kff.org. This information was reprinted from globalhealth.kff.org with kind permission from the Henry J. Kaiser Family Foundation. You can view the entire Kaiser Daily Global Health Policy Report, search the archives and sign up for email delivery at globalhealth.kff.org. © Henry J. Kaiser Family Foundation. All rights reserved.


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