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Positive Results For First Disease-Modifying Compound Targeting Protein Misfolding
Discoveries by Scripps Research Institute scientists have led to a promising new drug candidate - the first in its class - for patients with a genetic protein-misfolding disease. In results announced by the biopharmaceutical firm FoldRx Pharmaceuticals, Inc., the new drug tafamidis significantly halts disease progression for patients with a disease called Transthyretin (TTR) amyloid polyneuropathy (ATTR-PN).

Health Reform Price Tag Has Dems Scrambling To Lower Cost
The up to $1.6 trillion price tag for one version of health care reform has left Democrats scrambling to find a way to rein in costs while not sacrificing the basic tenets of a plan they favor, The Washington Post reports.
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Washington Post Column Examines Issues Surrounding Supreme Court Confirmation Hearings
"When a Supreme Court nominee such as Judge Sonia Sotomayor comes before the Senate for confirmation, she is promised a full, fair hearing," yet "every nominee"s path is booby-trapped by the history of previous confirmation battles," Washington Post columnist David Broder writes. Broder examines prior confirmation hearings, noting that the "[o]ne thing that may make it harder to forget the partisan and ideological battles of the past is that President Obama found reasons to oppose" Chief Justice John Roberts and Justice Samuel Alito while he was in the Senate.During Roberts" confirmation hearing, Obama said that although he was "sorely tempted to vote for Judge Roberts," he had issues with Roberts in cases where "precedent and rules of construction" are insufficient and where justice "can only be determined on the basis of one"s deepest values." Obama added that the rights of women and minorities are dependent on cases in which "the critical ingredient is supplied by what is in the judge"s heart." Obama said Roberts" record on women"s rights and other issues was not strong enough to quell doubts about Roberts" "deepest values."Broder continues, "Based on the Obama precedent, the White House can hardly complain if Republicans push beyond the question of Sotomayor"s qualifications and examine her values -- and her biases." He concludes, "Someday, the Senate may again be satisfied to examine only professional credentials, recognizing the uncertain dynamics of a nine-person bench," but while past precedents survive, "that is not likely" (Broder, Washington Post, 6/4).
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Crisis And Violence In Mumbai: Experiences From A Centre For Vulnerable Women And Children

In this week"s open access journal PLoS Medicine, Nayreen Daruwalla and colleagues describe the Centre for Vulnerable Women and Children, which serves clients coping with crisis and violence in the urban setting of Dharavi, Mumbai. In order to assist other developing crisis centres, the authors discuss factors that shaped the development of their Centre over six years. They emphasise how intervention is often guided by clients" desire to keep their families together. Successful intervention, the authors advise, requires strong links with health-care providers, police, legal services, and community-based organizations. Funding: The Centre for Vulnerable Women and Children receives funding from individual donors and the Sir Dorabji Tata Trust. This work was also supported by the Wellcome Trust (Reference 081052). The study sponsors did not have a role in the writing of the report or in the decision to submit the paper for publication. Citation: "Conflict, Crisis, and Abuse in Dharavi, Mumbai: Experiences from Six Years at a Centre for Vulnerable Women and Children." Daruwalla N, Fernandez A, Salam J, Shaikh N, Osrin D (2009) PLoS Med 6(7): e1000088. doi:10.1371/journal.pmed.1000088 PLoS Medicine


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