Popular Articles

After Myocardial Infarction Fatigue Is Common
Half of all patients who undergo myocardial infarction are experiencing onerous fatigue four months after the infarction. The patients who are most fatigued are those who perceive the infarction as a sign of chronic illness, those who experience the illness as difficult to control, and those who believe that the illness has a large impact on their life. These are the conclusions of a thesis presented at the Sahlgrenska Academy.

Eurand Successfully Completes Registration Procedure For Paracetamol ODT 250 And 500 Mg In The European Union
Eurand N.V. (NASDAQ: EURX), a specialty pharmaceutical company that develops enhanced pharmaceutical and biopharmaceutical products based on its proprietary pharmaceutical technologies, announced that the Dutch Medicines Evaluation Board (MEB) informed the Company that the Decentralized Procedure (DCP) for registration of Paracetamol 250 and 500 mg Orodispersible Tablets (ODT) in several EU countries has been successfully completed.
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Debate Continues On Administration Of Magnesium Sulfate To Pregnant Women To Prevent Cerebral Palsy In Pre-Term Infants
Cerebral palsy (CP) is the most prevalent chronic childhood motor disability with an estimated lifetime cost of nearly $1 million per individual. There is evidence that magnesium sulfate (MgSO4) can reduce the incidence of CP for very early preterm infants. Many thousands of pregnant women and their fetuses are exposed to MgSO4 every year in the United States for a variety of indications, and most obstetricians are comfortable with its use. Yet, there is still some controversy over whether magnesium sulfate is truly protective against CP. In three articles published in the June 2009 issue of theAmerican Journal of Obstetrics & Gynecology, the authors shed some light on the debate.
Cardiovascular

Ethics Review Of Research In The Context Of Humanitarian Relief Work

Two articles published this week in the open-access journal PLoS Medicine highlight the need for, and the practicalities of, getting appropriate ethical review of research done in the context of humanitarian relief. An article by Doris Schopper and colleagues describes the functioning of the Mç©decins Sans Frontiç¨res (MSF) independent ethics review board (ERB) and the framework used for ethics review by this board. The board, set up in 2001, currently comprises seven members from around the world, all independent of MSF. In 2008, the last full year of operation, the board reviewed 23 proposals covering a range of topic and study designs. As well as providing an overview the article describes some specific challenging ethical issues encountered by the board since its inception. In concluding the article, the authors say: "International humanitarian organizations such as MSF will be faced with even more complex health problems in the future as the global environment changes. Research to devise and test new interventions will remain an important part of MSF"s agenda, and will most probably increase. As this happens, a major concern will be to ensure that communities in which such research takes place are empowered to become true partners and that vulnerable individuals and groups are effectively protected The ethical oversight provided by the MSF ERB will be crucial in addressing these challenges." The editorial, written by the PLoS Medicine editors, discusses more generally the problems that can arise when research is done in such settings, and notes that ethical oversight of such research needs to be rigorous, but also pragmatic, and suggests what the role of journals should be. As the editorial notes, by supporting initiatives such as the MSF research ethics board, journals can help to address these ethical challenges, at the same time as ensuring that the research they publish adheres to accepted ethical standards. Article By Schopper and Colleagues: Funding: No funding was received for this work. Competing Interests: The authors have declared that no competing interests exist. Citation: "Research Ethics Review in Humanitarian Contexts: The Experience of the Independent Ethics Review Board of Medç©cins Sans Frontiç¨res." Schopper D, Upshur R, Matthys F, Singh JA, Bandewar SS, et al. (2009) PLoS Med 6(7): e1000115. doi:10.1371/journal.pmed.1000115 PLoS Medicine


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