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AXURA(R)/AKATINOL(R) Enhances Communication Abilities In Patients With Alzheimer÷´s Disease - for A Longer Integration In Social And Family Life
Memantine improves functional communication skills in patients with moderate to severe Alzheimer"s disease (AD), noticeable by caregivers. These are the study results discussed at the International Conference on Alzheimer"s Disease (ICAD). The data of two recent clinical trials support that AXURA®/AKATINOL® - an uncompetitive NMDA receptor antagonist - effects language skills in AD patients and improves cognitive abilities and functional communication. Leading neurologists emphasize that improvement of communication skills is a meaningful treatment target. Communication breakdown can trigger feelings of frustration in Alzheimer"s patients and these feelings may manifest as behavioral instability. This in turn is known to be a major of caregiver"s burden and distress.
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In Mouse Study Immune Cells Ameliorate Hypertension-Induced Cardiac Damage
Researchers in Berlin, Germany have found that a specific type of immune cell, the regulatory T lymphocyte (Treg) plays an important role in hypertension-induced cardiac damage. The injected Treg that they harvested from donor mice into recipient mice were infused with angiotensin II, a blood pressure-raising peptide. The Tregs had no influence on the blood pressure response to angiotensin II. Nonetheless, cardiac enlargement, fibrosis, and inflammation was sharply reduced by Treg treatment. Furthermore, the tendency to develop abnormal heart rhythms that could lead to sudden cardiac death was also reduced. Dr. Heda Kvakan and Dr. Dominik N. MÃøller at the Experimental and Clinical Research Center at the Max DelbrÃøck Center do not intend Treg as a therapy. However, a better understanding of how the immune system fits into hypertension-induced organ damage could result from these studies (Circulation, Vol. 119, No. 22, June 9, 2009, 2904-2912 ).*
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Report On Contaminated Drinking Water At Camp Lejeune
Two chemicals - trichloroethylene (TCE) and tetrachloroethylene (PCE) - found to have contaminated drinking water at Marine Corps Base Camp Lejeune from the 1950s to 1985 have been linked to certain diseases and disorders, including various cancers. A new report from the National Research Council, Contaminated Water Supplies at Camp Lejeune - Assessing Potential Health Effects, reviews scientific evidence about the potential adverse health effects that could occur after exposure to TCE, PCE, and other contaminants; recommends the usefulness of conducting additional studies on former residents of the base; and identifies scientific considerations that could help the U.S. Department of the Navy, under which the Marine Corps operates, set priorities on future actions. The report will be released at a 90-minute public briefing.
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Good Governance Guidance Published For Primary Care Trust Provider Committees, UK

The Appointments Commission and the Department of Health have published guidance to help Primary Care Trusts (PCTs) with their governance arrangements for Provider Committees. Provider Committees are a committee of a PCT Board, overseeing the operations of a PCT"s provider arm. The guidance published today, "Governance Arrangements to Support PCT Provider Committees", sets out core principles that should underpin the committee"s membership and make-up. Provider Committees need to be able to focus on quality, taking into account patient safety, patient experience and effective outcomes. This guidance will help to ensure that these committees are able to independently monitor, identify and mitigate risks to patients. The guidance also offers options for recruiting the independent members and outlines their roles and responsibilities. All NHS organisations need to be underpinned by robust governance arrangements that deliver independent challenge, scrutiny and accountability. This is particularly important for community services as they transform their patterns of service and organisational structures. The Department of Health is also giving more freedom to the NHS, to allow timescales to be set locally for when a PCT must choose an organisational structure under which to operate. Moving to locally-set timescales will enable the NHS to focus on driving-up quality and productivity in community services. Minister of State for Health, Mike O"Brien, said: "This guidance will support Primary Care Trusts in ensuring their local governance arrangements are fully in place and that PCT Provider Committees are well-equipped to provide both excellent management and clinical leadership and independent scrutiny and challenge." Andrea Sutcliffe, Chief Executive of the Appointments Commission, said: "We have sought to address the concerns raised by PCTs that they needed clear guidance that was sufficiently flexible to respond to local circumstances. This guidance will help to ensure that recruitment of independent members to Provider Committees is supported by a process that is fair, rigorous, transparent and that is able to stand up to public scrutiny." Jonathan Montgomery, Chair of Hampshire PCT, said: ""I welcome the publication of today"s guidance, which contains principled and practical advice on how to ensure robust governance arrangements are in place for PCT provided services. It promotes consistency of practice and conformity with the high standards governance that patients and the public expect of NHS organisations, while recognising that the precise form of arrangements depends on local circumstances. "It also contains important advice on the recruitment of independent members to Provider Committees, to provide the challenge and scrutiny necessary to give assurance that provider services are strategically led and that risks are effectively managed." The guidance is available to download from the Appointments Commission"s website http://www.appointments.org.uk/providergovernance. A Frequently Asked Questions section to update PCTs on key issues and developments is also available on this site. Department of Health, UK


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