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UNMC Scientists ID Molecule Superfamily That Causes Melanoma Spread
A University of Nebraska Medical Center research team has determined that a superfamily of molecules hold the secret to the progression and spread of melanoma -- the deadliest form of skin cancer. The study results were published in today"s issue of the British Journal of Cancer.

Special Reconstruction Method Improves Postoperative Quality Of Life In Gastric Cancer Patients
Given equivalent results with regards to survival, the impact of anastomotic methods on QOL becomes even more important. There is still no consensus on how to choose a reconstruction method for proximal gastrectomy in patients with upper third gastric cancer.
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Glimpsing The Birth Of Our Earliest Reproductive Cells
It has long been a mystery how the developing embryo designates those rare, precious cells destined to produce sperm and eggs -- enabling us to have offspring - since these primordial germ cells" existence is fleeting and hard to spot with the tools of biology. Now, using mouse embryonic stem cells, researchers in the Stem Cell Program at Children"s Hospital Boston have managed to recapitulate the creation of primordial germ cells (PGCs) in the lab, capturing the stem cells" gene activity as they differentiated to form PGCs. The findings, published in the July 5 issue of Nature, also offer a unique window on cancer.
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How Much Chronic Depression With Medical Disorders Affect Work Performance?

A group of Australian researchers investigated in medical disorders the effects of comorbid dysthymic disorder as compared to major depressive disorder (MDD) on health-related quality of life (HR-QoL) and disability days in the general population. In a population-based study 4,181 individuals were assessed for the presence of dysthymic disorder and depression, utilizing the Composite International Diagnostic Interview. Each participant received a thorough medical examination to assess the presence of comorbid somatic conditions. HR-QoL was evaluated using the Medical Outcomes Survey Short-Form 36 (SF-36) and disability days were provided by self-report. Descriptive statistics, analysis of variance and multivariable logistic regression were used. Comorbidity with illnesses from a maximum of 6 somatic disease groups was more prevalent in persons with dysthymic disorder (78.7%) than in those with MDD (70.4%). Persons with dysthymic disorder had a significantly lower mental health summary score in the SF-36 and more disability days than those with MDD. The physical health summary scores were not significantly different between participants with dysthymic disorder and MDD (after Bonferroni correction), suggesting that limitations in physical functioning due to comorbid medical conditions were similar in both affective disorder groups. The results of this investigation show that affective disorders comorbid with medical, somatic illnesses have a major impact on HR-QoL and disability with more pronounced effects in dysthymic disorder than in MDD. Differences in the time course of both conditions might contribute to this finding. The results support the need for an improved identification and treatment of affective disorders in patients with somatic illnesses. Psychotherapy and Psychosomatics


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