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Screening Prevents Aneurysm Deaths, But Questions Remain Over Cost Effectiveness
The national aortic screening programme in the UK should, in due course, prevent about half of all aneurysm deaths in men over 65 and will be extremely cost effective for the NHS, conclude researchers in a study published on bmj.com. However a second study, also published today, concludes that screening is not cost effective and calls for additional research into the long term outcomes and costs of screening.
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PAREXEL Reaches Milestone In Management Of Oncology Trials Over Last Five Years Involving 175,000 Patients Worldwide
PAREXEL International Corporation (Nasdaq: PRXL), a leading global biopharmaceutical services provider, announced it has reached a milestone in managing oncology-based clinical trials over the last five years, which have involved over 175,000 patients in hundreds of programs across 80 countries. PAREXEL will be marking this milestone during the American Society of Clinical Oncology (ASCO) Annual Meeting, to be held May 29 - June 2, 2009 in Orlando, Florida. PAREXEL"s hematology and oncology experts will be available during the ASCO meeting at Booth #1980 to discuss their capabilities to support the successful development of novel cancer treatments.
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Mortality Linked To Physical Activity Levels In Unfit Individuals
The least-fit segment of the population has twice the mortality risk of even those who are just a bit more in shape, according to a study published in the official journal of the American College of Sports Medicine.
Diagnostics

Identification Of New Breast Cancer-Promoting Gene

A team of researchers, at the Genome Institute of Singapore, has identified a new gene that seems to contribute to aggressive breast cancer behavior. As discussed in an accompanying commentary, by Gordon Mills and colleagues, the data generated in this study provide new insight into cellular processes underlying tumor cell proliferation and metastasis and identify potential new therapeutic targets. In the study, a new informatics approach was used to analyze microarray expression profiles of primary human breast cancers and the gene RCP was identified as a potential breast cancer-promoting gene. Importantly, this gene is found in a region of the genome frequently amplified in human breast cancer. In vitro analysis indicated that overexpression of RCP protein in normal human breast epithelial cells caused them to acquire tumor cell characteristics and function. Conversely, decreasing expression of RCP protein in human breast cancer cell lines reduced their in vitro tumor cell characteristics and in vivo ability to form tumors and metastasize when transplanted into immunodeficient mice. Further analysis identified some of the molecules affected by RCP overexpression, including the known tumor-promoting protein RAS. These data led the authors to suggest that one mechanism by which RCP promotes breast cancer is likely to be through activation of the RAS signaling pathway and that targeting RCP might provide a way to therapeutically inhibit this known tumor-promoting pathway. TITLE: RCP is a human breast cancer-promoting gene with Ras-activating function https://www.the-jci.org/article.php?id=37622 AUTHOR CONTACT: Lance David Miller Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA. Bing Lim Genome Institute of Singapore, Singapore, Singapore. ACCOMPANYING COMMENTARY TITLE: Genomic amplicons target vesicle recycling in breast cancer https://www.the-jci.org/article.php?id=40256 AUTHOR CONTACT: Gordon B. Mills University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Karen Honey Journal of Clinical Investigation


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