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Mayo Clinic Cancer Center Support Grant Renewed By NCI, Comprehensive Status Extended
The Mayo Clinic Cancer Center (MCCC) received an additional five years of National Cancer Institute (NCI) funding and re-designation as a comprehensive cancer center, according to Robert Diasio, M.D., the center"s director. Mayo Clinic has the only NCI-designated comprehensive cancer center conducting research at three distinct locations across the United States.

PerkinElmer Introduces Infrared Sensing And Photon Detection Solutions For Critical Environmental And Human Health Applications
PerkinElmer, Inc., a global leader focused on improving the health and safety of people and the environment, announced the introduction of four new products leveraging the Company"s innovative infrared sensing (IR) and photon detection technologies. Aimed at a range of OEM applications including energy conservation, enhanced home security, and clinical diagnostics applications, the new products will be showcased at the 16th annual Sensor + Test Fair taking place this week in NÃørnberg, Germany.
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Hormone Therapy Use Associated With Increased Risk Of Ovarian Cancer
Compared with women who have never taken hormone therapy, those who currently take it or who have taken it in the past are at increased risk of ovarian cancer, regardless of the duration of use, the formulation, estrogen dose, regimen or route of administration, according to a study in the July 15 issue of JAMA.
Nutrition

Ligand Initiates Clinical Trial With The Selective Androgen Receptor Modulator LGD-4033, A Potential Treatment Of Muscle And Bone Disorders

Ligand Pharmaceuticals Incorporated (NASDAQ:LGND) announced the initiation of a Phase I clinical trial with LGD-4033, a next-generation selective androgen receptor modulator (SARM) designed to provide the benefits of androgen receptor stimulation on skeletal muscle and bone without the side effects of currently marketed androgens. The Phase I study will evaluate the safety, tolerability and pharmacokinetic profile of orally administered LGD-4033. In preclinical studies, LGD-4033 demonstrated a highly tissue-selective profile with increased skeletal muscle mass and bone mineral density while largely sparing the prostate in males and masculinizing effects in females. Extensive preclinical studies with LGD-4033 demonstrate the following: - LGD-4033 is highly selective for the androgen receptor. - Gene transcriptional regulation assays using muscle or bone cells demonstrate that LGD-4033 is a potent, full agonist producing efficacy comparable to the natural steroidal androgen dihydrotestosterone. - In repeat oral dosing studies LGD-4033 increases skeletal muscle mass. - In the ovariectomized rat model of post-menopausal osteoporosis, LGD-4033 had anabolic activity in cortical bone, significantly increasing cortical bone formation rates, bone strength and bone density. LGD-4033 also suppressed bone turnover at cancellous bone sites, leading to an increase in lumbar spine bone density and strength. - In repeat oral dosing studies, LGD-4033 is a weak partial agonist on the prostate gland with more than 500-fold selectivity for muscle versus prostate. This indicates an absence of the prostatic hypertrophy that occurs with the currently marked androgens. "LGD-4033 has shown an excellent SARM profile to date in terms of efficacy, potency and selectivity, and it is potentially a novel therapeutic for muscle and bone-related disorders such as cachexia and frailty," said John L. Higgins, President and Chief Executive Officer of Ligand Pharmaceuticals. "This program is another example of how the success of Ligand"s research platform, which so far includes five approved drugs, allows us to continue investing in and strengthening a portfolio of promising candidates to address major clinical needs and commercial market opportunities." SARM Program SARMs are designed to elicit the desired biological effects without the undesirable side effects or potential risks over time of currently marketed androgens, providing a wide range of opportunities for the treatment of many diseases and disorders in both men and women. Tissue-selective androgen receptor agonists may provide utility in the treatment of a number of medical conditions, including frailty, cachexia, osteoporosis, sexual dysfunction and hypogonadism. Ligand has discovered orally active, non-steroidal SARM compounds, such as LGD-4033 and LGD-3303, based on tissue-specific gene expression and other functional, cell-based technologies. Ligand Pharmaceuticals


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