EndocrinologyNox(4)ious Requirement In Common Infant Tumor
Hemangiomas are the most common tumor of infancy. They are benign tumors derived from cells that line blood vessels (endothelial cells) and spontaneously regress as a child gets older. Jack Arbiser and colleagues, at Emory University School of Medicine, Atlanta, have now provided new insight into the molecules that control hemangioma growth and found that inhibiting a key molecule substantially inhibits hemangioma growth in a mouse model. Specifically, the protein Nox4 was found to be crucial for hemangioma growth in a mouse model and the drug fulvene 5 was found to be a potent in vitro inhibitor of Nox4 and to substantially inhibit in vivo hemangioma growth. The authors therefore suggest that targeting Nox4, potentially using fulvene derivatives, might provide a way to attenuate hemangioma growth.
Title:
Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice https://www.the-jci.org/article.php?id=33877
Author:
Jack L. Arbiser
Emory University School of Medicine, Atlanta, Georgia, USA.
Karen Honey
Journal of Clinical Investigation