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Popular Articles

Animal TB "Tracker" To Speed Drug And Vaccine Studies
Johns Hopkins researchers have developed a novel way to monitor in real time the behavior of the TB bacterium in mouse lungs noninvasively pinpointing the exact location of Mycobacterium tuberculosis. The new monitoring system is expected to speed up what is currently a slow and cumbersome process to test the safety and efficacy of various TB drug regimens and vaccines in animals. Plans are already under way for developing a similar system to monitor TB disease in humans.

North Carolina Residents Should Urge Lawmakers To Continue Funding HIV Program, Opinion Piece Says
The North Carolina legislature has proposed to eliminate the HIV Medicaid Case Management program, which "provides crucial support to people living with HIV, helping them access medical care, medications and the support services needed to live healthier lives," Jacquelyn Clymore of the Alliance of AIDS Services-Carolina and Beth Stringfield, member of the North Carolina AIDS Action Network, write in a Durham News opinion piece, adding, "We need to call legislators and let them know how important this program is to those living with HIV and ask them to return the program and its funding to the budget." They continue, "It is likely that additional budget cuts to HIV programs will be proposed, and we must speak out in support of state HIV prevention funding" (Clymore/Stringfield, Durham News, 6/13).
News of the day
Full Recovery After 16 Year Old Girl Has Transplanted Heart Removed
An article published Online First and in a future edition of The Lancet reports the extraordinary story of Hannah Clark who had a donor heart grafted onto her own after suffering heart failure as a baby. She underwent surgery ten and a half years after the transplant to remove the donor heart. This was possible because her own heart had recovered satisfactorily to work on its own. Today, three and a half years after this second operation, Hannah, now aged 16, has made a complete recovery. The article is the work of leading heart surgeons Professor Sir Magdi Yacoub, Imperial College London, Heart Science Centre, Harefield Hospital, Middlesex, UK, and consultant Victor Tsang, Great Ormond Street Hospital, London, UK and collaborators.
Endocrinology

Nox(4)ious Requirement In Common Infant Tumor

Hemangiomas are the most common tumor of infancy. They are benign tumors derived from cells that line blood vessels (endothelial cells) and spontaneously regress as a child gets older. Jack Arbiser and colleagues, at Emory University School of Medicine, Atlanta, have now provided new insight into the molecules that control hemangioma growth and found that inhibiting a key molecule substantially inhibits hemangioma growth in a mouse model. Specifically, the protein Nox4 was found to be crucial for hemangioma growth in a mouse model and the drug fulvene 5 was found to be a potent in vitro inhibitor of Nox4 and to substantially inhibit in vivo hemangioma growth. The authors therefore suggest that targeting Nox4, potentially using fulvene derivatives, might provide a way to attenuate hemangioma growth. Title: Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice https://www.the-jci.org/article.php?id=33877 Author: Jack L. Arbiser Emory University School of Medicine, Atlanta, Georgia, USA. Karen Honey Journal of Clinical Investigation


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