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Obama's Focus On Health Care Crucial To Reform
"After a week of international diplomacy, President Obama returns to Washington this week facing an even greater diplomatic challenge: nudging the large and controversial health-care reform package toward consensus on Capitol Hill," The Washington Post reports. Despite media reports of challenges including "the virtual wall of opposition among Republicans," "resistance among conservative Blue Dog Democrats over the potential cost," and "nervousness among progressives that the White House might compromise too much on a public insurance option," officials at the White House "remain publicly optimistic." White House Chief of Staff Rahm Emanuel said that the issues are just part of "the nature of what we"re doing," and that "we"ve never, on universal coverage, been this close to the goal line."
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Important Therapeutic Target For Breast Cancer: Newly Appreciated Membrane Estrogen Receptor
New research at Rhode Island Hospital has uncovered the biological effects of a novel membrane estrogen receptor, a finding that has potential implications for hormonal therapy for breast cancer. The study is published in the July edition of the journal Molecular Endocrinology. This new study by Edward Filardo, MD, and his research team further supports earlier published work by the group that linked the transmembrane receptor, GPR30/GPER-1, to specific estrogen binding, rapid estrogen signaling and breast cancer metastasis. "What is exciting about this new work," says Filardo, "is that it provides some insight into the influence of GPR30 at the cellular level. It shows that estrogen action through GPR30 allows for breast tumor cell survival, and not breast tumor cell proliferation." Prior studies by Filardo"s group showed that estrogen acts through GPR30 to promote the rapid release of preformed growth factors that are tethered to the surface of breast cancer cells. Their latest study was conducted in an effort to better understand the mechanism by which GPR30 triggered the release of epidermal growth factor (EGF) polypeptides from the surface of breast cancer cells.
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Progress In Osteoporosis: Free Online Journal
No time to keep abreast of the most important osteoporosis-related research? Progress in Osteoporosis, the free online journal published by the International Osteoporosis Foundation (IOF) on http://www.iofbonehealth.org/pio provides concise summaries of new research published in the preceding three to four months. The journal is edited by leading osteoporosis researcher and author, Professor Ego Seeman of the University of Melbourne, Australia.
Cardiovascular

Sciele Pharma And Plethora Solutions Announce Positive Results Of Final Phase III Pivotal Trial For PSD502 For Premature Ejaculation

Sciele Pharma Inc., a Shionogi Company, and Plethora Solutions Holdings PLC ("Plethora" - AIM:PLE), announced that a second and final Phase III double-blind, placebo-controlled study of PSD502 for the treatment of premature ejaculation ("PE") has met all co-primary endpoints of Intra-vaginal Ejaculation Latency Time ("IELT"), Index of Premature Ejaculation ("IPE," Ejaculatory Control, Sexual Satisfaction and Distress domains). This successful study, involving patients from the USA, Canada and Europe, is one of two pivotal Phase III studies that were run in parallel with identical protocols. The previously announced Phase III study was conducted entirely in Europe, and its successful outcome was reported in November 2008. Data from the two studies will be combined for submission for regulatory approval in the USA and Europe. Ed Schutter, President and Chief Operating Officer of Sciele Pharma, said, "We are pleased with these initial Phase III efficacy results in this final Study for PSD502, which, upon FDA approval, would be the first prescription treatment in the United States for premature ejaculation." Phase III Study Details Each Phase III study was a multi-centre, randomised, double blind, placebo-controlled efficacy study that recruited a total of 540 patients across the two studies. Patients were treated for a 12-week period with an optional open-label phase of up to nine months. Outcome of Second Phase III Study Entirely consistent with the first study, analyses show that PSD502 produced a highly clinically and statistically significant increase from baseline in all co-primary study endpoints. The intra-vaginal ejaculation latency time (IELT) was increased at least six-fold with PSD502 when compared to baseline (pAbout PSD502 PSD502 is a proprietary formulation of two marketed drugs, lidocaine and prilocaine, dispensed by a metered dose aerosol developed for the treatment of premature ejaculation, a disorder affecting between 25% and 30% of men in the USA and Europe. In May 2007, Plethora signed an exclusive license agreement with Sciele Pharma, Inc., ("Sciele"), to market PSD502 for premature ejaculation in the USA. In May 2009 Sciele acquired global rights to the product. About Sciele Pharma, Inc. Sciele Pharma, Inc., a Shionogi Company, is a pharmaceutical company specializing in sales, marketing and development of branded prescription products focused on the therapeutic areas of Cardiovascular, Diabetes, Women"s Health and Pediatrics. The Company"s Cardiovascular and Diabetes products treat patients with high cholesterol, hypertension, high triglycerides, unstable angina and Type 2 diabetes; its Women"s Health products are designed to improve the health and well-being of women and mothers and their babies; and its Pediatrics products treat allergies, asthma, coughs and colds, and attention deficit and hyperactivity disorder (ADHD). Founded in 1992 and headquartered in Atlanta, Georgia, Sciele employs more than 1000 people. The Company"s success is based on placing the needs of patients first, improving health and quality of life, and implementing its business platform - an Entrepreneurial Spirit, Innovation, Execution Excellence, Simplicity, and Teamwork. For more information please, visit http://www.sciele.com. On October 9, 2008, Shionogi & Co., Ltd. and Sciele Pharma announced the completion of Shionogi"s acquisition of Sciele. Sciele is now an indirect wholly owned subsidiary of Shionogi. About Shionogi & Co., Ltd. Shionogi & Co., Ltd., headquartered in Osaka, Japan, is a major research-driven pharmaceutical company dedicated to placing the highest value on patients. Shionogi"s Research and Development currently targets three therapeutic areas: Infectious Diseases, Pain, and Metabolic Syndrome. The Company has provided such innovative medicines as Crestor and Doripenem, which have been successfully delivered to millions of people who need them. In addition, Shionogi is engaged in some new research areas such as allergy and cancer. Contributing to the health of patients around the world through development in these therapeutic areas is Shionogi"s primary goal. For more details, please visit http://www.shionogi.co.jp. Plethora


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