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Popular Articles

Rolofylline Did Not Demonstrate Efficacy For Acute Heart Failure In Clinical Trial
Merck & Co., Inc. said that preliminary results for the pivotal Phase III study of rolofylline (MK-7418), the Company"s investigational medicine for the treatment of acute heart failure, show that rolofylline did not meet the primary or secondary efficacy endpoints. While Merck will continue to analyze the data with outside experts, the Company will not file applications for regulatory approval this year. The results from this study will be presented at a medical meeting later this year.

Hospital Disaster Potential Highighted By Swedish Study
Factors that lead to emergency department overcrowdings, ambulance diversions and other incidents that endanger patient safety have been revealed. A study published in BioMed Central"s open access Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine has shown that reductions in the number of hospital beds and downsizing or closure of emergency departments may create a dangerous loss of "surge capacity".
News of the day
President Obama Picks New York City Health Commissioner Thomas Frieden For CDC Director
President Obama on Friday appointed New York City Health Commissioner Thomas Frieden as CDC director, according to Obama administration officials, the New York Times reports. According to the Times, Frieden, an infectious disease specialist, has "cut a high and sometimes contentious profile" in his seven years as health commissioner in New York City, during which time he has advocated for a smoking ban in restaurants and bars, made HIV testing part of routine medical exams and protected a program that distributes 35 million condoms a year. According to the Times, Frieden is expected to take office next month. The Times reports that he will "inherit a host of immediate and long-term problems," including questions surrounding a vaccine for the H1N1 influenza virus, also known as swine flu, health care reform and organizational issues at CDC.The Times reports that a potential advantage for Frieden is a positive relationship with likely FDA Commissioner Margaret Hamburg, who also was New York City health commissioner. Frieden would work with Hamburg to combat the H1N1 flu virus and to re-evaluate the U.S. food safety system (Harris/Hartocollis, New York Times, 5/15).
Medical Devices

TAU Develops Superior Method For Coating Orthopaedic And Dental Implants

Tel Aviv University researcher Prof. Noam Eliaz of the TAU School of Mechanical Engineering has developed an electrochemical process for coating metal implants which vastly improves their functionality, longevity and integration into the body. The new process could vastly improve the lives of people who have undergone complicated total joint replacement surgeries so they can better walk, run and ultimately avoid rejection of the implant by their bodies. "The surface chemistry, structure and morphology of our new coatings resemble biological material," explains Prof. Eliaz. "We"ve been able to enhance the integration of the coating with the mineralized tissue of the body, allowing more peoples" bodies to accept implants." His new coating resulted in a 33% decrease in the level of materials failure, or delamination, in these implants. Prof. Eliaz presented his findings to the 215th meeting of the Electrochemical Society in San Francisco in May 2009. In addition, a new 12-week implantation study, recently published in the journal Acta Biomaterialia, favorably compared the performance of the Tel Aviv University coatings to those of current commercial coatings. Giving your joints an electrochemical bath Today"s surgeons can reconstruct joints in the human body using metal structures implanted to take the place of the natural joint. In order to better integrate the new addition to the adjacent bone, implants are often coated with synthetic hydroxyapatite, which is similar to the main inorganic constituent of enamel, dentin and vertebrate bone. The properties of this coating are crucial to the function and life of the implant in the body. Prof. Eliaz"s advance is in the application technique of the coatings rather than the elements used in the coatings themselves. Instead of the traditional plasma-spraying technique, he and his team from the Tel Aviv University Materials and Nanotechnologies Program have developed a way to electrochemically deposit synthetic hydroxyapatite. In place of plasma-spraying the coating onto the metal, the metal implant is placed into a bath of electrolyte solution and an electric current is applied. According to Prof. Eliaz, a good coating is crucial to the stable fixation of the implant in the surrounding bone. Since human bones naturally contain apatite, covering the implant with a synthetic version allows the body to register the implant as similar to a real bone. This ensures integration and fixation of the implant, and also prevents poisonous materials from leaking from the metal of the implant into the blood stream. Could spur new bone growth Prof. Eliaz has discovered that his method of coating circumvents the disadvantages of plasma-spraying. The electrochemical process allows synthetic hydroxyapatite to more closely mimic the real material. Examined under a microscope, it is virtually indistinguishable from the body"s own material - which helps the body accept a new implant. The next-generation coating will include nano-particles to reinforce the coating. It will also have the potential to incorporate biological material or drugs during the process itself. "We can incorporate biological materials" because the electrochemical process works at lower temperatures, says Prof. Eliaz. "The reinforcement of nanoparticles will improve the mechanical properties and may also improve the biological response. Drug incorporation may reduce the risk of post-surgery infection and even catalyze the growth of the bone." George Hunka American Friends of Tel Aviv University


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