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Swedish Discovery May Provide New Treatments For Alcohol Dependence
Researchers at the Sahlgrenska Academy, Gothenburg, have discovered a new brain mechanism involved in alcohol addiction involving the stomach hormone ghrelin. When ghrelin"s actions in the brain are blocked, alcohol"s effects on the reward system are reduced. It is an important discovery that could lead to new therapies for addictions such as alcohol dependence.
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CytRx's Tamibarotene Receives Positive Opinion From The Committee For Orphan Medicinal Products In The European Union For Treatment Of APL
CytRx Corporation (NASDAQ: CYTR), a biopharmaceutical research and development company engaged in the development of high-value human therapeutics, announced that its lead drug candidate tamibarotene has received official notification from the Committee for Orphan Medicinal Products (COMP) of the European Medicines Agency (EMEA) that a positive opinion was made regarding the application for orphan medicinal product for the treatment of acute promyelocytic leukemia (APL). The positive opinion of the COMP has now been forwarded to the EU commission for final approval and publication in the community register. This favorable opinion for tamibarotene in the European Union (EU) is in addition to the Orphan Drug Designation for APL and Fast Track Designation for the treatment of adult patients with relapsed or refractory APL following treatment with all-trans retinoic acid (ATRA) and arsenic trioxide granted by the U.S. Food and Drug Administration (FDA) in October 2007.
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Johns Hopkins School Of Medicine To Offer New Degree Program In Informatics
A new, intensive, one-year master"s degree program designed to prepare graduates for informatics leadership positions in clinical, public health and scientific settings will be offered beginning in September by the Johns Hopkins University School of Medicine. The Maryland Higher Education Commission (MHEC) approved the new program in June.
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The Development Of Mechanosensitivity

Researchers of the Max DelbrÃøck Center for Molecular Medicine (MDC) Berlin-Buch, Germany, have gained crucial insight into how mechanosensitivity arises. By measuring electrical impulses in the sensory neurons of mice, the neurobiologists and pain researchers Dr. Stefan G. Lechner and Professor Gary Lewin were able to directly elucidate, for the first time, the emergence of mechanosensitivity. At the same time they were able to show that neurons develop their sensitivity to touch and pain during different developmental phases but always coincidentally with the growth of the neuronal pathways. (EMBO Journal, 2009, doi:10.1038/emboj.2009.73).* The sensory neurons, which are sensitive to touch and pain, are located in the dorsal root ganglia between the intervertebral discs. The neurons receive the stimulus and convert it into electrical signals that are conveyed to the brain. Signal transduction has been investigated very thoroughly, which has led to the development of drugs that block the transduction of pain signals to the brain. Very little, however, is known about how stimulus sensitivity actually emerges. Using the patch-clamp technique in isolated cells of mouse embryos, the MDC researchers succeeded in measuring tiny electrical currents in the cell membranes after a mechanosensory stimulus. "These measurements are extremely difficult," Dr. Lechner explained, "which is why only very few laboratories in the world are specialized in this area." The researchers in Berlin-Buch were able to show that the sensory neurons in the mouse embryo have already fully developed their mechanosensitivity competence on embryonic day 13. That corresponds to about the end of the sixth month of pregnancy in humans. For this development the neurons do not require any nerve growth factor, which is why the researchers suspect that this process is driven by a genetic program. In contrast, the competence to sense pain in the sensory neurons can only develop with the aid of nerve growth factor (NGF). It takes place at a later stage in embryonic development and even after birth. *Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development Stefan G Lechner, Henning Frenzel1, Rui Wang1 and Gary R Lewin* Department of Neuroscience, Max DelbrÃøck Center for Molecular Medicine, Berlin-Buch, Germany *Corresponding author Barbara Bachtler Helmholtz Association of German Research Centres


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