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New Mechanism Fundamental To The Spread Of Invasive Yeast Infections Identified
A group of researchers led by Carnegie Mellon University Biological Sciences Professor Aaron Mitchell has identified a novel regulatory gene network that plays an important role in the spread of common, and sometimes deadly, yeast infections. The findings, which establish the role of Zap1 protein in the activation of genes that regulate the synthesis of biofilm matrix, will be published in the June 16, 2009, issue of PLoS Biology, a peer-reviewed open-access journal from the Public Library of Science.

Opinion: Obama's Africa Policy; Maternal Health
President Obama is expected to arrive in Accra, Ghana, Friday night, the AP/Google.com reports. White House adviser Michelle Gavin said the president chose to travel to Ghana "because it"s such an admirable example of strong, democratic governance, vibrant civil society" (Babington, 7/10). The following are opinion pieces reflecting on his trip and Africa policy:
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Array BioPharma Announces Top-Line Results In Two Phase 1 Clinical Trials
Array BioPharma Inc. (NASDAQ: ARRY) announced top-line results from its Phase 1 seven-day dose escalation trial up to 1,200 mg daily of p38 inhibitor, ARRY-797, in healthy volunteers. In addition, the top-line results were announced in a second study, where ARRY-797 was evaluated in a 28-day Phase 1b trial in stable rheumatoid arthritis (RA) patients taking methotrexate. This study compared two doses of ARRY-797 to placebo.
Medical Devices

The 'Other' Cruciate Ligament: Newer Treatments For PCL Tears

While major advances have been made in the understanding of posterior cruciate ligament (PCL) anatomy and reconstruction, a literature review published in the July 2009 issue of the Journal of the American Academy of Orthopaedic Surgeons (JAAOS) finds that there must be continued advances in basic science research in order to determine the best course of treatment for those with PCL injuries. "An ACL (anterior cruciate ligament ) tear is an injury of instability; a PCL tear is an injury of disability," said study author Matthew Matava, MD, Associate Professor, Department of Orthopedic Surgery, Washington University School of Medicine, in Chesterfield, Missouri. "With a PCL injury, your knee won"t buckle on you tomorrow, but in a few months or years it may become painful and not as strong or stable as it was prior to the injury. PCL tears are less frequently discussed because they are often left undiagnosed and the patient does not seek treatment for what they assumed was a mild injury." PCL injuries are assessed by grades: - Grade 1: Partial tear (non-surgical treatment options recommended) - Grade 2: Isolated, near complete tear (non-surgical treatment options recommended) - Grade 3: Complete PCL torn, with other ligament injuries (surgery often recommended, but not always) Two newer surgical options, along with one traditional method, are currently used to treat Grade 3 injuries: - Traditional: One-bundle bone graft passed through a tunnel in the tibia (shin bone). One-bundle grafts are made thicker than two-bundle grafts, but may not be as effective because they attach at a single point. - Newer: Two-bundle graft (studied for the past 10 years). Two-bundle grafts use thinner individual grafts, but their total graft volume is thicker. They may be more effective than one-bundle grafts because they attach at two different points. - Newer: Inlay reconstruction is an approach whereby a graft is screwed into the back of the tibia avoiding a tunnel through the front of the tibia. According to Dr. Matava, basic science data suggests that it is favorable to use a two-bundle graft over a one-bundle graft, and that an inlay reconstruction is preferable to a graft passing through a tibial tunnel. Inlay reconstruction is different, he says, because the graft does not get stretched around the tibial tunnel and is prevented from stretching out and/or fraying. "I like this procedure because I have had improved results compared to prior patients of mine that underwent the traditional method with the graft placed through the tibial tunnel," said Dr. Matava. "Additionally, there is biomechanical evidence that the benefits I have noticed are real." There have not been any randomized prospective studies to date, however, comparing the two methods. Some orthopaedic surgeons, however, believe these procedures are more complicated and therefore more risky; they also disagree on how much tension to use on the graft. If a patient has a PCL injury, the orthopaedic surgeon should first determine the level of injury in order to decide on the best treatment option. Because PCL surgery is technically challenging, a patient needing surgery should seek out an orthopaedic surgeon with experience performing PCL reconstructions. "Although we believe the newer treatments are better, we still must prove it," said Dr. Matava. "In order to do that, we must continue with our research, and follow patients over the course of several years to determine whether their treatments were successful." About the PCL The PCL is a ligament that prevents the shin bone from moving backwards, and PCL injuries occur most frequently in individuals involved in motor vehicle accidents when the knee is bent and the shin forcefully strikes the dashboard. Athletes also experience PCL tears when they fall on the front of their knee, causing it to bend back. Injuries to the PCL should not be confused with ACL injuries. Nearly 200,000 ACL surgeries are performed in the U.S. each year; PCL surgeries are estimated to be approximately 20 times less common. Disclosure: Matthew Matava, MD or a member of his immediate family serves as a paid consultant to or is an employee of ISTO Technologies and Schwartz Biomedical, and has received research or institutional support from Breg. Neither of the other authors of the study or a member of their immediate families has received anything of value from or owns stock in a commercial company or institution related directly or indirectly to the subject of this article: Evan Ellis, MD and Brian Gruber, MD. JAAOS AAOS


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