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FoldRx Pharmaceuticals Announces Positive Results From Pivotal Phase II/III Clinical Study Of Tafamidis
FoldRx Pharmaceuticals, Inc. (FoldRx) announced positive results from its pivotal Phase II/III clinical study of the company"s lead compound, tafamidis (Fx-1006A), in patients suffering from TTR amyloid polyneuropathy (ATTR-PN), a fatal orphan disease also known as Familial Amyloid Polyneuropathy (FAP). Liver transplantation is the only currently available treatment option for this progressive neurodegenerative disease. Preliminary results from the first randomized controlled trial ever completed in this disease demonstrate that tafamidis treatment significantly halts disease progression in ATTR-PN, reduces the burden of disease after 18 months compared to placebo, and appears to be safe and well-tolerated.

Preconceptional Folic Acid Supplements Are Associated With Reduced Risk Of Premature Birth
Taking folic acid supplements for at least a year before conception is
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New York Times Examines Program To Help Orphans Survive 'Fragile Days Of Infancy'
The New York Times examines a program being offered at an orphanage in Tanzania that provides emotional and physical support for newborns and young children who are at a high risk of death after losing their mothers in infancy. "Africa is full of at least 50 million orphans, the legacy of AIDS and other diseases, war and high rates of death in pregnancy and childbirth," the newspaper writes. "With the numbers increasing every day, Africans are struggling to care for them, often in ways that differ strikingly from the traditional concept of an orphanage in the developed world."
Diagnostics

What Is A Virus? What Is A Viral Infection?

A virus (from the Latin virus meaning toxin or poison) is a microscopic organism consisting of genetic material (RNA or DNA) surrounded by a protein, lipid (fat), or glycoprotein coat. Viruses are unique organisms because they cannot reproduce without a host cell. After contacting a host cell, a virus will insert genetic material into the host and take over the host"s functions. The cell, now infected, continues to reproduce, but it reproduces more viral protein and genetic material instead of its usual products. It is this process that earns viruses the classification of "parasite". How are viruses spread? Viruses may spread vertically (from mother to child) or horizontally (from person to person). A virus"s ability to spread depends on the makeup of the virus. Interesting articles What are bacteria? What is fungus? What are fungi? What is herpes? What is genital herpes? What is hepatitis? Symptoms, causes and treatments. What is swine flu? What is measles? What are the symptoms of measles? What is polio? What causes polio? What is flu (influenza)? What are the symptoms of flu? Some viruses can spread by simple contact, exchanges of saliva, coughing, or sneezing. Some require sexual contact, while others go through the fecal-oral route via contaminated food or water. Still other viruses require an insect like a mosquito to carry the virus from person to person. What diseases are caused by viruses? Several human diseases are caused by viruses. These include: *Smallpox *The common cold *Measles *Chickenpox *Hepatitis *Influenza *Human papilloma virus *Shingles *Herpes *Polio *Rabies *Ebola *Hanta fever *HIV (the virus that causes AIDS) *Cold sores *SARS (Severe acute respiratory syndrome) *Dengue *Epstein-Barr virus *Some types of cancer How do we fight viruses? When the body"s immune system detects a viral infection, it begins to respond in a generic way. A process begins called RNA interference, which is crucial to fighting viruses because it degrades the viral genetic material and enables cells to survive the infection. The immune system also produces specific antibodies that are capable of binding to viruses and making them non-infectious. In addition, the body"s T cells are sent to destroy the virus. Although most viral infections result in a protective response from the immune system, viruses such as HIV specialize in evading the immune system by using a number of different techniques. Neurotropic viruses are also very capable of avoiding our natural immune system"s response to infection. How are viruses prevented and treated? Whereas bacterial infections can be treated with antibiotics, viral infections require either vaccinations to prevent them or antiviral drugs to treat them. Vaccinations are generally the cheapest and most effect way to prevent viruses. Currently, vaccinations exist for polio, measles, mumps, rubella, and smallpox among others. In fact, vaccinations have been instrumental in eliminating diseases such as smallpox and reducing other viral diseases to extremely rare status. Virus vaccinations consist of a weakened form of the virus (live-attenuated viruses) or viral proteins called antigens. Live-attenuated vaccines carry the risk causing the original disease in people with weak immune systems. Antiviral drugs have been developed largely in response to the AIDS pandemic. These drugs do not destroy the pathogen but instead inhibit their development. Antiviral medications are relatively harmless to the host. Written by Peter Crosta M.A. Copyright: Medical News Today Not to be reproduced without permission of Medical News Today


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