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Opinion Piece Criticizes Winfrey For 'Unbalanced' Medical Advice On Hormone Replacement Therapy
Oprah Winfrey "has scored good ratings with her health episodes" of her television show, but "in doing so, she seems to have thrown therapeutic caution to the wind," such as on her shows featuring actress Suzanne Somers" opinions on bioidentical hormone replacement therapy, Salon contributor and physician Rahul Parikh writes in an opinion piece. Somers, while advocating for the use of bioidentical HRT as a safe alternative to traditional HRT for postmenopausal women, said she used "mega-doses of bioidenticals continuously and aggressively," according to Parikh. Parikh writes that Somers, on television and in her 2007 book, "argues that these hormones are more natural, more effective and safer than what doctors prescribe." According to Parikh, "In reality, ...÷ there are no good medical studies to back up those claims."Parikh says that although "what Somers was advocating was radically different from standards of medical care," Winfrey "was not concerned" and even said that Somers ""might be a pioneer,"" Parikh continues. Winfrey billed the episode as part of a ""great debate"" on hormone therapy, but she "didn"t ask about whether [Somers"] super-hormone regimen could have contributed to Somers" history of breast cancer"; "her hysterectomy, the result of pre-cancerous changes in her uterus from her use of HRT"; or the "validity of Somers" book"s s, many of whom are neither experts in women"s health or endocrinology, nor board-certified physicians, nor experienced researchers," Parikh states. He adds, "It"s not that Winfrey doesn"t try to maintain medical credibility in her shows," but "her efforts seem subpar," noting that her show "reaches millions of people, while each doctor can reach only one patient at a time." Parikh concludes, "That could easily be corrected by Winfrey providing more thought and balance in her medical advice" (Parikh, Salon, 5/15).

Patient Response To Therapy For Gastrointestinal Stromal Tumors May Be Predicted By Gene Signature
Researchers at Fox Chase Cancer Center uncovered a genetic pattern that may help predict how gastrointestinal stromal tumor (GIST) patients respond to the targeted therapy imatinib mesylate (Gleevec). Moreover, their findings point to genes that could be suppressed in order to make these tumors respond more readily to imatinib.
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Working Towards An Optical Integrated Circuit

ETH Zurich researchers have successfully created an optical transistor from a single molecule. This has brought them one step closer to an optical computer. Internet connections and computers need to be ever faster and more powerful nowadays. However, conventional central processing units (CPUs) limit the performance of computers, for example because they produce an enormous amount of heat. The millions of transistors that switch and amplify the electronic signals in the CPUs are responsible for this. One square centimeter of CPU can emit up to 125 watts of heat, which is more than ten times as much as a square centimeter of an electric hotplate. Photons instead of electrons This is why scientists have been trying for some time to find ways to produce integrated circuits that operate on the basis of photons instead of electrons. The reason is that photons do not only generate much less heat than electrons, but they also enable considerably higher data transfer rates. Although a large part of telecommunications engineering nowadays is based on optical signal transmission, the necessary encoding of the information is generated using electronically controlled switches. A compact optical transistor is still a long way off. Vahid Sandoghdar, Professor at the Laboratory of Physical Chemistry of ETH Zurich, explains that, "Comparing the current state of this technology with that of electronics, we are somewhat closer to the vacuum tube amplifiers that were around in the fifties than we are to today"s integrated circuits." However, his research group has now achieved a decisive breakthrough by successfully creating an optical transistor with a single molecule. For this, they have made use of the fact that a molecule"s energy is quantized: when laser light strikes a molecule that is in its ground state, the light is absorbed. As a result, the laser beam is quenched. Conversely, it is possible to release the absorbed energy again in a targeted way with a second light beam. This occurs because the beam changes the molecule"s quantum state, with the result that the light beam is amplified. This so-called stimulated emission, which Albert Einstein described over 90 years ago, also forms the basis for the principle of the laser. Focusing on a nano scale Jaesuk Hwang, first author of the study and a scientific member of Sandoghdar"s nano-optics group, explains that, "Amplification in a conventional laser is achieved by an enormous number of molecules." By focusing a laser beam on only a single tiny molecule, the ETH Zurich scientists have now been able to generate stimulated emission using just one molecule. They were helped in this by the fact that, at low temperatures, molecules seem to increase their apparent surface area for interaction with light . The researchers therefore needed to cool the molecule down to minus 272 degrees Celsius (minus 457.6 degrees Fahrenheit), i.e. one degree above absolute zero. In this case, the enlarged surface area corresponded approximately to the diameter of the focused laser beam. Switching light with light By using one laser beam to prepare the quantum state of a single molecule in a controlled fashion, scientists could significantly attenuate or amplify a second laser beam. This mode of operation is identical to that of a conventional transistor, in which electrical potential can be used to modulate a second signal. Thus component parts such as the new single molecule transistor may also pave the way for a quantum computer. Sandoghdar says, "Many more years of research will still be needed before photons replace electrons in transistors. In the meantime, scientists will learn to manipulate and control quantum systems in a targeted way, moving them closer to the dream of a quantum computer." Reference: J. Hwang, M. Pototschnig, R. Lettow, G. Zumofen, A. Renn, S. Gç¶tzinger, V. Sandoghda: A single-molecule opzical transistor, Nature (2009) 460, 76-80,doi:10.1038/nature08134 ETH Zuerich


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