Swedish Discovery May Provide New Treatments For Alcohol Dependence
Researchers at the Sahlgrenska Academy, Gothenburg, have discovered a new brain mechanism involved in alcohol addiction involving the stomach hormone ghrelin. When ghrelin"s actions in the brain are blocked, alcohol"s effects on the reward system are reduced. It is an important discovery that could lead to new therapies for addictions such as alcohol dependence.
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What Is An Aneurysm? What Causes Aneurysm?
An aneurysm occurs when part of a blood vessel (artery) or cardiac chamber swells, - either the blood vessel is damaged or there is a weakness in the wall of the blood vessel. As blood pressure builds up it balloons out at its weakest point. The swelling can be quite small or very large - when large it tends to extend along the blood vessel. As the aneurysm grows there is a greater risk of rupture - this can lead to severe hemorrhage, and other complications, including sudden death. According to Medilexicon"s medical dictionary, an aneurysm is a "Circumscribed dilation of an artery or a cardiac chamber, in direct communication with the lumen, usually resulting from an acquired or congenital weakness of the wall of the artery or chamber." Visit our specialized news sections Cardiovascular / Cardiology News Cholesterol News Statins News Heart Disease News Hypertension (High Blood Pressure) News Stroke News Obesity / Weight Loss News Vascular News Sleep / Sleep Disorder News Smoking / Quit Smoking News An aneurysm can occur in any part of the body. They tend to most commonly occur on the wall of the aorta - the large trunk artery that carries blood from the left ventricle of the heart to branch arteries. The aorta goes down through the chest and into the abdomen, where it divides into the iliac arteries (two branches). There are two main types of aneurysms: *Aortic aneurysm - occurs in the aorta. Can be abdominal, or thoracic (higher up). *Cerebral aneurysm - occurs in an artery in the brain. People of any age and either sex can have an aneurysm, although they are more common in men and people over 65 years of age. What are the symptoms of an aneurysm? Symptoms are linked to how big the aneurysm is, how fast it is growing and its location. Very small aneurysms which do not grow may go completely unnoticed. A large cerebral aneurysm (in the brain) may press on nerve tissue and trigger numbness in the face, or problems with the eyes. Cerebral (brain) aneurysm symptoms The following symptoms may be experienced before a cerebral aneurysm ruptures: *Very severe headache that occurs suddenly *Nausea *Vomiting *Eyesight problems *Seizures (fits) *Loss of consciousness *Confusion *A drooping eyelid *Stiff neck *Light sensitivity If the cerebral aneurism bursts it will cause bleeding in the brain and a hemorrhagic stroke - it can also cause intracranial hematoma (blood leaks into the area surrounding the brain causing a blood clot in the skull). Aortic aneurysm symptoms The vast majority of aortic aneurysms occur in the patient"s abdominal aorta. It is not uncommon for a patient to have an aneurysm and experience no symptoms for several years. Many of them are difficult to detect because of this. Some aortic aneurysms will never rupture. It is hard to predict which ones will never grow, which grow slowly, and which ones grow rapidly. When symptoms occur, they tend to include: *A throbbing sensation in the abdomen *Back pain *Abdominal pain - this pain frequently spreads towards the back If the aneurysm continues to grow and presses on the spine or chest organs the patient may experience: *Coughing *Loss of voice *Breathing difficulties *Problems swallowing Sometimes an aortic aneurysm can be discovered by a GP (general practitioner, primary care physician) when performing a routine examination of the abdomen. He/she may detect a lump that pulses at the same rate as the patient"s heartbeat - it is often located high up in the abdomen, slightly to the right. What causes an aneurysm? Brain (cerebral) aneurysm causes: *Weakness in the artery wall (usually present since birth) *Hypertension (high blood pressure) *Arteriosclerosis (plaques of cholesterol, platelets, fibrin, and other substance form on the arterial wall) Most cerebral aneurysms develop at the forks or branches in arteries because the walls in these sections are weaker. They most commonly form at the base of the brain - but can form anywhere in the brain. Abdominal aortic aneurysm causes: *Atherosclerosis - accumulation of fatty deposits (cholesterol) on the artery walls. *Smoking - this is a major risk factor in the development of aortic aneurisms. Smoking contributes to atherosclerosis, hypertension and the acceleration of aneurysm growth. Compared to women who have quit smoking, women smokers are four times more likely to have an abdominal aortic aneurysm repair or ruptura, according to researchers at the VA Medical Center, Minneapolis. *Hypertension - especially if it is poorly controlled (not treated at all, or not treated properly). *Vasculitis (infection in the aorta) - this is an uncommon cause, and seems to run in families. *Cocaine use - Cocaine users in their mid-40s had more than four times the risk of coronary artery aneurysms as non-users, according to a study at Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital. Thoracic aortic aneurysm causes: About 1 in 4 aortic aneurysms occur in the thoracic area of the aorta (higher up in the chest). Causes are the same as with aortic aneurysms, plus the following below: *Marfan syndrome - this is a genetic disorder of the connective tissue; it is a much less common cause of aortic aneurysm. Interesting related article What is a heart attack? What causes a heart attack? What is heart failure? What causes heart failure? What is the difference between Diabetes Type 1 and Diabetes Type 2? What is hypertension? What causes hypertension? What are statins? How statins work and the side effects of statins What is cholesterol? What causes high cholesterol? What is a stroke? What causes a stroke? What is embolism? What are the different types of embolism? What is deep vein thrombosis (DVT)? What is fat? How much fat should I eat? What is salt? How much salt should I eat? *Previous aorta injury - people with a previous injury to the aorta, such as aortic dissection (tear in the wall of the aorta) have a higher risk of developing a thoracic aortic aneurysm. *Traumatic injury - this could be cause by a vehicle accident or a bad fall. How is an aneurysm diagnosed? Aortic aneurism diagnosis: The majority of abdominal aortic aneurysms are discovered when doctors are examining a patient for some other reason, such as during a chest X-ray or ultrasound, according to this report by The Mayo Clinic. If an aortic aneurysm is suspected some specific tests will be ordered, they include: *Abdominal ultrasound - the patients lie on their back and some warm gel is applied to the skin of their abdomen prior to the examination. The gel reduces the chances of air pockets forming on the surface of the skin when the device (transducer) is placed on it. The transducer is moved along the surface of the abdominal skin and sends images to a monitor - from this monitor it is possible for a trained technician to detect a potential aneurysm. *CT (computerized tomography) scan - X-rays are used to create a 3-dimensional picture of the target area. *MRI (magnetic resonance imaging) scan - magnets and radio waves produce 2-dimensional and 3-dimensional pictures of the target area. *Regular screening for those at risk - as many aneurysms present no symptoms, people aged 60 or over and who are deemed to be at risk of developing an aortic aneurysm are advised to undergo regular screening. These may include men over 65 who have smoked regularly (even if they have given up), as well as men with a family history of abdominal aortic aneurysm. This report concluded that "The National Aortic Screening Programme" in the UK should, in due course, prevent about half of all aneurysm deaths in men over 65 and will be extremely cost effective for the NHS. Cerebral aneurysm diagnosis: Patients who suddenly have a very severe headache, or other symptoms which may indicate a ruptured cerebral aneurysm will most likely undergo some tests to find out whether there is any subarachnoid hemorrhage or some other type of stroke. If bleeding is detected, the emergency care team will determine whether an aneurysm was the cause. Patients who do not have a ruptured cerebral aneurysm, but have symptoms such as pain behind the eye, changes in vision, or paralysis on one side of their face, will also undergo tests. These tests may include: *A CT (computerized tomography) scan - X-rays are used to create a 3-dimensional picture of the target area. Multidetector computed tomography (MDCT) angiography is highly accurate in depicting intracranial aneurysms, according to a study carried out by researchers at the Department of Radiology at Klinikum Duisburg in Germany. *A cerebrospinal fluid test - anyone who had a subarachnoid hemorrhage will probably have red blood cells in the cerebrospinal fluid (the fluid surrounding the brain and spine). Patients who have symptoms of a ruptured aneurysm but had a CT scan which did not show any evidence of bleeding will undergo this cerebrospinal fluid test; called a lumbar puncture or spinal tap. *MRI (magnetic resonance imaging) scan - this test is better than a CT scan at detecting a ruptured aneurysm. *Cerebral arteriogram (cerebral angiogram) - a catheter is inserted into a large artery, usually entering the patient in his/her groin, and threads past the heart to the brain arteries. A special dye goes into the arteries via the catheter which shows up in X-ray images - the doctor can then see details about the conditions of the arteries and the site of a ruptured aneurysm. As this quite an invasive procedure, it is only generally used when other procedures have not provided enough data. Treatment for an aneurysm Aortic aneurysm treatment: The aim is to prevent the aneurysm from bursting. There are usually two choices - 1. Watch and wait. 2. Surgery. How big the aneurysm is, how fast it"s growing, and sometimes its location are vital factors in determining what treatment to use. *If the aneurysm is small - if the patient"s aneurysm isPages: [1] 2