Health Insurance
This Independence Day, the Los Angeles County Department of Public Health, in conjunction with Ralphs and L.A. Care Health Plan, is helping LA County residents declare their freedom from smoking by giving away free two-week starter kits of nicotine patches or gum. The quit smoking aids are free to residents of LA County at 47 participating Ralphs Pharmacies throughout the county between the hours of 1 p.m. - 8 p.m., while supplies last.
New research describes a molecular tool that shows great promise as a therapeutic for human acute myeloid leukemia (AML), a notoriously treatment-resistant blood cancer. The study, published by Cell Press in the July 2nd issue of the journal Cell Stem Cell, describes exciting preclinical studies in which a new therapeutic approach selectively attacks human cancer cells grown in the lab and in animal models of leukemia.
Scientists at Singapore"s Bioprocessing Technology Institute (BTI) have made a novel discovery about how the gene, "Fas-apoptosis inhibitory molecule" (FAIM), protects both immune and liver cells from apoptosis, or programmed cell death.
Several statistical and biological issues need to be addressed in order to improve biomarker identification for early detection of cancer, according to a commentary published online July 2 in the Journal of the National Cancer Institute.
Pregnant women who are indigenous to the Andes Mountains deliver more blood and oxygen to their fetuses at high altitude than do women of European descent. The study helps explain why babies of Andean descent born at high altitude weigh more than European babies born at altitude.
Entangled in all the controversial drama surrounding the sudden death of Pop-Icon Michael Jackson is the issue of his three children"s paternity. With conflicting facts out there, many people are talking about the possibility that his children may have been born through embryo donation and adoption. This practice is not new. Many families are successfully birthing healthy babies from frozen embryos throughout the United States.
A comprehensive overview that explores the prospects and progress of synthetic inhibitors to target cell cycle kinases in cancer forecasts that "novel compounds with increased potency, improved kinase specificity and favorable drug like properties will soon be available for clinical evaluation."
A similarity in brain disturbance between insects and people suffering from migraines, stroke and epilepsy points the way toward new drug therapies to address these conditions.
Existing drugs used in the treatment of Parkinson"s disease could be repositioned for use in the treatment of extreme drug-resistant tuberculosis, which kills about 2 million people each year, according to a study led by researchers at the University of California, San Diego. The rise of these strains of TB throughout the world, including industrialized countries, poses a great threat to human health.
In times of doubt and uncertainty, many Americans turn to self-help books in search of encouragement, guidance and self-affirmation. The positive self-statements suggested in these books, such as "I am a lovable person" or "I will succeed," are designed to lift a person"s low self-esteem and push them into positive action. According to a recent study in Psychological Science, a journal of the Association for Psychological Science, however, these statements can actually have the opposite effect.
Shire plc (LSE: SHP, NASDAQ: SHPGY), the global specialty biopharmaceutical company, has announced that it will present key scientific data on its Attention Deficit Hyperactivity Disorder (ADHD) treatments lisdexamfetamine dimesylate (CII) and investigational non-scheduled guanfacine extended release, at a national scientific meeting of psychiatrists being held May 16 -21 in San Francisco, CA.
BioCis Pharma Ltd., a privately held drug development company with its headquarters in Turku, Finland, announced positive results from its Phase IIa clinical trial of ProtoCure(TM) emulsion cream, the company"s novel topical drug for dermatology. This double-blind, placebo-controlled study, conducted in Finland, included 13 patients with mild to moderate atopic dermatitis who applied the ProtoCure emulsion cream to the affected skin areas twice daily for up to four weeks. The objectives were to evaluate the tolerability, pharmacokinetics, and efficacy of the topical treatment.
ThromboGenics NV (Euronext Brussels: THR) and co-development partner BioInvent International (OMXS: BINV) announce that they have started recruitment of a second cohort of patients for their Phase II trial of TB-402. This follows completion of recruitment of the first cohort of 100 patients ahead of schedule. TB-402 is a novel, long acting anticoagulant that is being developed for the prevention of deep vein thrombosis (DVT) following orthopaedic surgery. The decision to move ahead with the second cohort of this trial follows unanimous advice from the external efficacy and safety monitoring board to proceed using a higher dose of TB-402.
Resuming sexual activity is expressed by patients as extremely important after a myocar÷dial infarction (MI). In spite of this, sex counselling is an area of nursing practice that is frequently neglected and needs more evidence-based knowledge.
The Centers for Disease Control and Prevention (CDC) informed in its weekly update on Friday evening, 3rd July, 2009, that the total number of confirmed human cases of swine flu A(H1N1) infection stands at 33,902, including 170 deaths.
ETH Zurich researchers have successfully created an optical transistor from a single molecule. This has brought them one step closer to an optical computer.
A newly discovered mechanism controls whether muscle cells in blood vessels hasten the development of both atherosclerosis and Alzheimer"s disease, according to an article published online in the journal Nature.
Common genetic variations spread across five genes raise a person"s risk of developing the most frequent type of brain tumor, an international research team reports online in Nature Genetics.
In a discovery that rebuffs conventional scientific thinking, researchers at Georgetown University Medical Center (GUMC) have discovered a novel way to block the activity of the fusion protein responsible for Ewing"s sarcoma, a rare cancer found in children and young adults.
Patients who suffer from transient ischaemic attack (so-called "mini-strokes") are more likely to receive rapid assessment and care if they attend a hospital which has organised stroke care services, according to the results of a survey published in the Medical Journal of Australia.
GE (NYSE:GE), and Asklepios Hospital Group today signed an agreement to create their first project in German healthcare to comprehensively address environmental issues. The renovation and expansion of one of the hospitals owned by Asklepios in Hamburg, Germany, known as the "Green Hospital" project, will be their pilot hospital in Europe entirely planned and designed on ecological principles.
In a bid to reduce levels of undiagnosed HIV in Cardiff, HIV and sexual health charity Terrence Higgins Trust (THT) is encouraging people who may have been at risk to attend a local service offering one-hour HIV testing. One in four people who have HIV in the UK are undiagnosed, and there are now more people living with the condition than ever before.
It has long been a mystery how the developing embryo designates those rare, precious cells destined to produce sperm and eggs -- enabling us to have offspring - since these primordial germ cells" existence is fleeting and hard to spot with the tools of biology. Now, using mouse embryonic stem cells, researchers in the Stem Cell Program at Children"s Hospital Boston have managed to recapitulate the creation of primordial germ cells (PGCs) in the lab, capturing the stem cells" gene activity as they differentiated to form PGCs. The findings, published in the July 5 issue of Nature, also offer a unique window on cancer.
At the start of the next round of international negotiations in Geneva (28 June-5 July) [1], ASH is releasing a major new report showing that if a protocol on tobacco smuggling were to be adopted, it could
Inovio Biomedical Corporation (NYSE Amex:INO), a leader in DNA vaccine design, development and delivery, announced today that it will make multiple presentations at the Annual Conference of DNA Vaccines in Asia 2009 being hosted by the International Society of DNA Vaccines July 9 - 10 at the Beijing International Convention Center. The conference, with the theme, "Advancing DNA Vaccine Technology," is co-chaired by David B. Weiner, Ph.D., professor of pathology, University of Pennsylvania School of Medicine, and chairman of Inovio"s scientific advisory board.
A consortium of European and Australian scientists doing a genome-wide association study found three gene variants were strongly linked to
Acupuncture originates from China and has been practiced there for thousands of years. Although there are records of acupuncture being used hundreds of years ago in Europe, it was during the second half of the twentieth century it began to spread rapidly in Western Europe, the United States and Canada. Acupuncture involves the insertion of very thin needles through the patient"s skin at specific points on the body - the needles are inserted to various depths. We are not sure how acupuncture works scientifically. However, we do know that it does have some therapeutic benefits, including pain relief and alleviation from nausea caused by chemotherapy.
Men who drink 22 or more units of alcohol a week have a 20% higher rate of admissions into acute care hospitals than non-drinkers, researchers from the University of Glasgow have found.
As part of its continued drive to reduce people"s risk of developing coronary heart disease, the Food Standards Agency has today published revised, voluntary salt reduction targets for industry to meet by 2012.
ATS Medical, Inc. (Nasdaq: ATSI), manufacturer and marketer of state-of-the-art cardiac surgery products and services, announced FDA clearance and the first implant of the ATS Simulus(R) Semi-Rigid Annuloplasty Band. The Simulus Semi-Rigid Annuloplasty Band was developed through the Company"s collaboration with Genesee BioMedical and represents the latest addition to the expanding portfolio of valve repair products.
Scientists at Burnham Institute for Medical Research (Burnham) have discovered that specialized complex sugar molecules (glycans) that anchor cells into place act as tumor suppressors in breast and prostate cancers. These glycans play a critical role in cell adhesion in normal cells, and their decrease or loss leads to increased cell migration by invasive cancer cells and metastasis. An increase in expression of the enzyme that produces these glycans, í²3GnT1, resulted in a significant reduction in tumor activity. The research was published in the journal Proceedings of the National Academy of Sciences.
Global biomedical sciences companies invested more than US$500 million in
Patients with atrial fibrillation, common in those with advanced chronic heart failure, have an increased risk of hospitalization due to heart failure, according to new research from researchers at the University of Alabama at Birmingham (UAB). The findings, published in June in the European Heart Journal, also suggest that atrial fibrillation is not associated with an increased risk of death in heart failure patients, contradicting previous assumptions.
The Minister for Health & Children published the Report of the Working Group on certain accounting issues related to the Health Service Executive.
From his jail cell, Scott Roeder, the man charged in the murder of abortion provider George Tiller, has been sending inflammatory pamphlets calling such killings justifiable and corresponding with radical antiabortion-rights groups, the AP/Boston Globe reports. The pamphlets call Paul Hill, who was convicted of murdering abortion provider John Bayard Britton and his bodyguard in 1994, an "American hero" and quotes some of Hill"s writing about how murdering abortion providers is acceptable. Roeder obtained the pamphlets from the antiabortion-rights group Army of God. Roeder also has been corresponding with the Rev. Donald Spitz, founder of Army of God, and antiabortion-rights advocate Linda Wolfe, who has been jailed about 50 times for antiabortion activities and is a close friend of the woman convicted of shooting Tiller in the arms in 1993. The AP/Globe reports that the FBI and Department of Justice declined to comment on whether they are concerned about Roeder"s mailings. Last month, Roeder in an interview said that there are "many other similar events planned around the country as long as abortion remains legal." Roeder has not been accused of breaking any laws because of the correspondence (AP/Boston Globe, 7/4).
The Mayo Clinic Cancer Center (MCCC) received an additional five years of National Cancer Institute (NCI) funding and re-designation as a comprehensive cancer center, according to Robert Diasio, M.D., the center"s director. Mayo Clinic has the only NCI-designated comprehensive cancer center conducting research at three distinct locations across the United States.
The National Science Foundation (NSF) has awarded a four-year, $1,450,000 grant to the Network Dynamics and Simulation Science Laboratory (NDSSL) at the Virginia Bioinformatics Institute (VBI) at Virginia Tech and partners to develop petascale computing environments that model billions of individuals in extremely large social and information networks.
BioNews publishes a controversial editorial by Dr Gedis Grudzinskas, Director of Fertility Focus Professional Services. If the same standards were applied to ivf centres as cardiac surgery, one in five ivf centres in the uk would be closed immediately.
GeckoSystems Intl. Corp. (PINKSHEETS: GCKO) announced that they expect pent-up demand for their cost effective, home based eldercare personal robots. This new type of modern eldercare will postpone, if not eliminate, many elderly persons from having to endure the loneliness and loss of independence when living in nursing homes, and other assisted living facilities. Their families can now better manage the difficult decisions regarding independence they allow their now dependent aged parent while minimizing the concern and risk the adult caregiving child is willing to assume to enable an acceptable level of independence for their now dependent parent. GeckoSystems is a dynamic leader in the emerging Mobile Service Robot industry revolutionizing their development and usage with "Mobile Robot Solutions for Safety, Security and Service™."
In this week"s open access journal PLoS Medicine, Nayreen Daruwalla and
Riders across the country will take to the streets on Friday, May 15 in celebration of National Bike to Work Day. In support of their efforts and enthusiasm, the American Physical Therapy Association (APTA) offers tips for reducing the risk of bicycle-related injury through proper bike fit.
Patients who survive an initial diagnosis of breast cancer often succumb to the disease years later when the cancer shows up in a different part of the body. Now, scientists have identified key signals that support the long term survival of breast cancer cells after they have spread to the bone marrow. The research, published by Cell Press in the July issue of the journal Cancer Cell, may lead to development of treatment strategies that decrease the likelihood of breast cancer recurrence in the bone and other organs.
African-American women who were younger at menarche, or the onset of their menstrual periods, were more likely to report a history of childhood sexual abuse, according to a new study led by a researcher at Boston University"s Slone Epidemiology Center. The results suggest that a history of sexual abuse may increase the risk of early menarche (i.e., onset of menstrual periods before age 12 years).
A new prostate cancer "homing device" could improve detection and allow for the first targeted treatment of the disease.
In response to a study published online in the BMJ, comparing the performance of two cardiovascular risk assessment tools, British Heart Foundation (BHF) Medical Director, Professor Peter Weissberg, said:
ERT (Nasdaq: ERES), a leading provider of centralized ECG, ePRO, eClinical technology and other services to the biopharmaceutical, medical device and related industries, announced today the launch of a unique online web interface - My Study Portal(TM). Following the successful launch of ERT"s new website, My Study Portal is aimed at enhancing the accuracy and efficiency of cardiac safety data management in clinical trials.
The final analysis of the largest efficacy trial of a cervical cancer vaccine is published today in The Lancet. The study, involving 18,644 women, confirmed GlaxoSmithKline"s Cervarix(R) is highly effective at protecting against the two most common cervical cancer-causing human papillomavirus (HPV) types, 16 and 18. The study also showed that the vaccine provides cross-protection against HPV types 31, 33 and 45, the three most common cancer-causing virus types beyond 16 and 18.
Hologic, Inc., (Hologic or the Company) (Nasdaq: HOLX), a leading developer, manufacturer and supplier of premium diagnostics, medical imaging systems and surgical products dedicated to serving the healthcare needs of women, announced the U.S. Food and Drug Administration (FDA) has approved the Company"s premarket approval (PMA) application for the Adiana(R) permanent contraception system. The Adiana system is designed to provide women a minimally-invasive, non-incision alternative to traditional, surgical means of permanent contraception. In January 2009, Hologic received CE marking approval for the Adiana system and commenced marketing and sales of this product in certain European countries.
With the recall of the cold remedy Zicam nasal spray for possibly causing some people to lose their sense of smell and the prior failures of vitamin C and echinacea to prove effective in trials, viruses seem to be winning the war on colds.
The resumption of fighting in Mogadishu, Somalia"s capital, has forced the majority of people living in the Yaqshid, Karan, and Abdul Azziz districts in the north of the city to flee, according to the international medical humanitarian organization Doctors Without Borders/Mçİdecins Sans Frontiç¨res (MSF). Continuous shelling, explosions, and open combat among various armed groups have claimed the lives of dozens of civilians and plunged the city into chaos. As a consequence, MSF has been forced to close its medical centers in the area.
Despite some roadblocks, Senate Democrats are trying to hold true to their pledge to pass health care reform legislation by the August recess, Roll Call reports.
According to WHO (World Health Organization), the total number of confirmed swine flu A(H1N1) cases of human infections stands at 9,830, including 79 deaths. The numbers of confirmed cases are rising by approximately 1,000 per day, says WHO. Japan has seen confirmed cases rise sharply over the last few days.
Significant and widespread cognitive problems appear to exist in schizophrenia in its earliest phase, making it very hard for people with the disorder to work, study or be social, according to a new study published by the American Psychological Association.
Michael R. Taylor, J.D., a nationally recognized food safety expert and research professor at George Washington University"s School of Public Health and Health Services, will return to the U.S. Food and Drug Administration to serve as senior advisor to the commissioner.
A new Australian Institute of Health and Welfare/University of Sydney report on General Practice highlights the critical role GPs play in keeping the Australian community healthy, AMA Federal President, Dr Andrew Pesce, said today.
Thallion Pharmaceuticals Inc. (TSX:TLN) announced that it has suspended patient enrollment in its Phase II trial evaluating TLN-232 as a treatment for metastatic melanoma, due to an ongoing dispute with the licensor. A binding arbitration proceeding has been initiated and Thallion will re-evaluate the status of the program based on the outcome of the adjudication.
A study by researchers from Duke University and the University of North Carolina-Chapel Hill and published in PLoS Medicine has found that upon infection "three lines of attack by the immune system are quickly neutralized by HIV," findings they hope "will provide a better understanding of how to develop a vaccine to protect against the virus," the Raleigh News & Observer reports. The study, lead by Duke"s Barton Haynes, showed that HIV, "once considered a slow if stealthy invader, actually works incredibly fast at disarming key immune fighters in the body." Haynes said scientists still have a difficult task in developing a vaccine, adding, "It would have to be different than any other vaccine made" (Avery, 7/7).
Iron supplements do not increase the likelihood of contracting malaria and should not be withheld from children at risk of the disease, despite World Health Organisation (WHO) guidelines to the contrary, a new review by Cochrane Researchers suggests.
Psychological interventions intended to prevent the development of post-traumatic stress disorder (PTSD) in the early stages after a traumatic experience have not been shown to be effective, Cochrane Researchers have concluded. This systematic review focused on multiple-session treatments for everyone involved, irrespective of the presence of symptoms. Two previous reviews found single session interventions to be ineffective.
Progressive resistance strength training not only helps older adults become stronger but also makes their everyday life easier, a Cochrane Review suggests.
Healthy young mice treated with erythropoietin show lasting improved performance in learning and other higher brain functions. Researchers writing in the open access journal BMC Biology tested the cognitive effects of the growth factor, finding that it improved the sequential learning and memory components of a complex long-term cognitive task.
Scientists at the Swedish medical university Karolinska Institutet and Linkçĥping University are well on the way to creating the first artificial nerve cell that can communicate specifically with nerve cells in the body using neurotransmitters. The technology has been published in an article in Nature Materials.
A new Northwestern University-led study of human colon, pancreatic and lung cells is the first to report that cancer cells and their non-cancerous cell neighbors, although quite different under the microscope, share very similar structural abnormalities on the nanoscale level.
Cardiovascular diseases (CVD) are the main cause of early death and disability in Europe, accounting each year for the loss of more than 2 million lives and costing the EU economy an estimated 192 billion euros. Top level stakeholders and EU and national policymakers are meeting in Brussels to assess current prevention programs and to develop a strategy for Cardiovascular Health.
Yale University researchers have found that a single gene plays a key role in the development of atherosclerosis in mice. The research provides insight into the causes of atherosclerosis, or the hardening of the arteries caused by a buildup of plaque.
Persons with higher levels of adiponectin, a protein that is produced by fat cells and that has anti-inflammatory and insulin-sensitizing properties, have an associated lower risk of type 2 diabetes, according to an analysis of previous studies, reported in the July 8 issue of JAMA.
Two London teaching hospitals have been chosen to take the lead in the fight against hospital bugs nationwide. They will try out new disinfection products for a three month period and if successful these may be used in other hospitals across the NHS. Barts and The London NHS Trust and the Royal Free Hampstead NHS Trust will now trial new technologies designed to combat infections.
Rasilez® (aliskiren), the first new type of high blood pressure medicine in more than a decade, has been approved for use in Japan. Rasilez directly inhibits renin9, an enzyme that triggers a process leading to high blood pressure and organ damage. The Ministry of Health, Labour and Welfare (MHLW) in Japan approved Rasilez for the treatment of high blood pressure alone or in combination with other high blood pressure medicines.
Fate Therapeutics, Inc. announced the presentation of data from its research on small molecule modulators of the Wnt pathway for osteo-regeneration at the 7th Annual Meeting of the International Society for Stem Cell Research (ISSCR) in Barcelona, Spain. In its findings, the Company demonstrated that selected Wnt activators induce the differentiation of mesenchymal stem cells to mature, bone-forming osteoblasts. The study highlights the potential for using small molecule Wnt activators as osteogenic agents. Because osteogenic agents stimulate positive bone growth, they may offer an improved course of action in clinical settings ranging from orthopedics to osteoporosis as compared to current medications aimed at preventing bone decay.
New research reveals around 22 million people suffered back pain in the last year - just under half of all UK adults (45 percent)[1]. More than one in four UK adults - nearly 13 million people - suffered from knee pain in the last year. Over 80 percent of the people with back or knee pain still suffer some pain after undergoing treatment recommended by a healthcare professional. Bupa is making APOS Treatment for knee and lower back pain available in the UK for the first time. The breakthrough treatment can eliminate the need for prescription pain relief for seven out of 10 people[2].
The inactivated flu vaccine does not appear to be effective in preventing influenza-related hospitalizations in children, especially the ones with asthma. In fact, children who get the flu vaccine are more at risk for hospitalization than their peers who do not get the vaccine, according to new research that will be presented on Tuesday, May 19, at the 105th International Conference of the American Thoracic Society in San Diego.
The issue of whether government-subsidized health care programs should include coverage for abortion procedures is gaining attention as Congress continues drafting health care reform legislation, Time reports. Currently, the Hyde Amendment -- a legislative provision attached annually to major spending bills since 1976 -- prohibits states from using federal Medicaid funds to pay for abortion. All but 17 states have similar restrictions on their own funds. Although current versions of health reform legislation do not yet address the issue of abortion, congressional s involved in the process say that an explicit ban on abortion coverage could have "much further-reaching implications" than the Hyde Amendment. According to Time, the restrictions could deny abortion coverage to women whose private insurance plans currently cover the procedure. A 2002 Guttmacher Institute survey found that nearly 90% of private insurers cover abortion procedures. Under the legislation being worked on in three House committees, U.S. residents with incomes up to 400% of the poverty level -- about $88,000 annually for a family of four, or $43,000 for an individual -- would be eligible for government subsidies to help purchase coverage. However, antiabortion-rights lawmakers are pushing to prohibit those subsidies from being used to purchase health insurance policies that include abortion coverage, Time reports. Such restrictions would mean that women who currently have abortion coverage in their private plans would have to give up the benefit. According to Time, such a provision also "would raise all sorts of other questions if insurers were allowed to discriminate among their customers based on whether or not they are using federal dollars to pay for their policies."Pelosi Negotiating With House Dems Over ConcernsLast week, 19 House Democrats sent a letter to House Speaker Nancy Pelosi (D-Calif.) stating that they "cannot support any health care reform proposal unless it explicitly excludes abortion from the scope of any government-defined or subsidized health insurance plan." They also said that abortion "must be addressed clearly in the bill text" of the legislation. The signers of the letter include Reps. Bart Stupak (Mich.) and Charlie Melancon (La.), both members of the House Energy and Commerce Committee, one of the three panels with jurisdiction over health care reform. According to Time, Pelosi"s office is attempting to address the concerns through negotiations.Poll Shows Support for Reproductive Health CoverageMeanwhile, abortion-rights advocates are "pushing back" against those seeking to specifically exclude abortion coverage in health care reform legislation, Time reports. The National Women"s Law Center on Monday released results of a nationwide poll of 1,000 likely voters showing that 71% of respondents favor including reproductive services like birth control and abortion in health care reform (Tumulty, Time, 7/8). The poll also found that 72% would oppose exclusion of abortion coverage from any national health care plan (Eaton, Plain Dealer, 7/7). In addition, 75% of respondents said that an independent commission, not Congress, should determine what medical services are included in the basic benefits offered under health reform. Congress also is weighing giving that power to HHS Secretary Kathleen Sebelius (Time, 7/8).Judy Waxman, NWLC vice president, said that 80% of employer-based insurance plans provide coverage for abortion services, adding that "people will be angry if they don"t get to keep what they already have" under any public insurance option (Cleveland Plain Dealer, 7/7). Waxman said Congress should "refrain from practicing medicine and instead let medical professionals determine what health care services will be included in a benefits package" (Time, 7/8).
New estimates of the likelihood that a latent case of tuberculosis (TB) will become active have resulted in a roughly 50 percent increase over previous estimates of the number of people needed to be screened (NNS) to prevent an active infection, limiting the cost effectiveness of screening in many Center for Disease Control and Prevention (CDC)-defined risk groups, according to an analysis conducted by experts in the epidemiology of the disease.
A condition known as congenital adrenal hyperplasia, or CAH, is easily treatable but frequently overlooked or misdiagnosed, leading to infertility and other "perplexing symptoms," the New York Times reports. CAH is a hormone deficiency that leads to excess production of androgens, which can hinder ovulation in women and cause low sperm count in men. It also can cause short stature, body odor, acne, irregular menstruation and excessive hair growth. The condition can be diagnosed through a blood test and treated with small doses of the steroid dexamethasone, which can reverse symptoms in three months to two-and-one-half years.According to Maria New, a leading authority on CAH and a professor of pediatrics and human genetics at Mount Sinai School of Medicine, the disease occurs in one in every 100 people in the general population. It is more common among certain ethnic groups, occurring in one in 27 Ashkenazi Jews and one in 40 Hispanics. Not everyone with the condition has symptoms or needs to be treated. The most severe form of the disease, classic CAH, can result in ambiguous genitalia in girls, while the milder nonclassical form sometimes produce no symptoms, the Times reports.Many fertility clinics do not test for the disease or only test after attempting other treatments. Some obstetricians are unaware of CAH and its effect on fertility, according to Zev Rosenwaks, director of the Center for Reproductive Medicine at New York Presbyterian-Weill Cornell hospital. CAH also can be confused with polycystic ovarian syndrome -- which has some similar symptoms -- or early puberty in younger patients (Tarkan, New York Times, 7/7).
Celebrating its fifth year in the virtual world, the 2009 American Cancer Society Relay For Life of Second Life is set for July 18-19 as avatars representing cancer survivors, caregivers, their families and the millions of passionate supporters gather virtually to celebrate the lives of those who have battled cancer, remember loved ones lost, and join the American Cancer Society in fighting for every birthday, threatened by every cancer in every community.
Inter Press Service News Agency examines the shortcomings of treatments for neglected tropical diseases - which, according to the Drugs for Neglected Diseases Initiative (DNDi), account "for 12 percent of the global disease burden," and 1.3 percent of the new drugs developed between 1975 to 2004. "The diseases in question account for the deaths of 500,000 people annually, mostly in sub-Saharan Africa, but drug development is biased towards the prospect of high profits, which diseases of the poor like sleeping sickness and visceral leishmaniaisis are unable to offer," IPS writes.
New consensus has been reached by a panel of leading European experts on the guidelines for the treatment of acute minor wounds which states that healing is accelerated by a moist wound environment.
In letters to Senators Charles Grassley and Herb Kohl, and Representatives Henry Waxman, Bart Stupak , John Dingell & Barney Frank, the Law Project for Psychiatric Rights (PsychRights) has exposed massive Medicaid Fraud. While working on PsychRights v. Alaska , its lawsuit to prohibit the State of Alaska from the largely ineffective and always harmful psychiatric drugging of children and youth, PsychRights "discovered that it is illegal for the vast bulk of these prescriptions to be reimbursed by Medicaid."
Transplant patients rely on drugs to prevent graft rejection, but at the cost of serious side effects. The class of immunosuppressive drugs known as calcineurin inhibitors (examples are cyclosporine and tacrolimus) can damage patients" kidneys and lead to high blood pressure, among other problems.
bioMçİrieux (Paris:BIM), a world leader in the field of in vitro diagnostics, announced that an AOAC-RI certification has been granted (No. 060903) to the VIDAS® UP E. coli O157 (Including H7) method for screening beef, selected produce and irrigation water. Food manufacturers in the U.S. and many other countries rely on AOAC-RI certified testing methods to release their products on the market. The new solution is based on recombinant phage protein, the latest technology available for food pathogen screening, which offers unique specificity and sensitivity. E. coli O157:H7 is a potentially lethal strain of Escherichia coli that has caused many food outbreaks in the United States, Canada, Japan, and Europe.
Array BioPharma Inc. (NASDAQ: ARRY) announced top-line results from its Phase 1 seven-day dose escalation trial up to 1,200 mg daily of p38 inhibitor, ARRY-797, in healthy volunteers. In addition, the top-line results were announced in a second study, where ARRY-797 was evaluated in a 28-day Phase 1b trial in stable rheumatoid arthritis (RA) patients taking methotrexate. This study compared two doses of ARRY-797 to placebo.
A new study carried out at the University of Haifa sheds light on how first and second languages are represented in the brain of a bilingual person. A unique single case study that was tested by Dr. Raphiq Ibrahim of the Department of Learning Disabilities and published in the Behavioral and Brain Functions journal, showed that first and second languages are represented in different places in the brain.
An aneurysm occurs when part of a blood vessel (artery) or cardiac chamber swells, - either the blood vessel is damaged or there is a weakness in the wall of the blood vessel. As blood pressure builds up it balloons out at its weakest point. The swelling can be quite small or very large - when large it tends to extend along the blood vessel. As the aneurysm grows there is a greater risk of rupture - this can lead to severe hemorrhage, and other complications, including sudden death.
Siemens Enterprise Communications has won a four year multi-million pound framework contract to provide Barts and The London NHS Trust with an integrated Enterasys fixed and wireless LAN and security infrastructure. The first phase in a three stage communications programme, the new infrastructure - due for completion in 2010 - will provide a single network able to handle all optical images, video streaming and traffic from multiple wireless devices and PCs for 300 beds at Barts hospital.
Amylin Pharmaceuticals, Inc. (Nasdaq: AMLN) announced positive results from a 28-week dose-ranging study of pramlintide/metreleptin, a combination treatment comprising pramlintide, an analog of the natural hormone amylin, and metreleptin, an analog of the natural hormone leptin, in overweight and obese patients. This Phase 2 study successfully characterized patients who responded best to treatment and also provided important information to inform dose selection.
Human Genome Sciences, Inc. (Nasdaq: HGSI) announced publication by The New England Journal of Medicine of the results of two pivotal animal efficacy studies, which showed the life-saving potential of the Company"s human monoclonal antibody drug raxibacumab (ABthrax(TM)), as well as the results of human safety studies, which supported the use of raxibacumab in the event of life-threatening inhalation anthrax disease.
Schering-Plough Corporation (NYSE: SGP) announced that Schering-Plough K.K., the company"s country operation in Japan, has received marketing approval for REMERON(R) /Reflex(R) (mirtazapine)15 mg Tablets for the treatment of major depressive disorder.(1) The product was developed jointly with Meiji Seika Kabushiki Kaisha, Ltd. Schering-Plough and Meiji Seika will market the product under the trade names, REMERON(R) and Reflex(R), respectively. REMERON is currently available in more than 90 countries worldwide.
Hereditary angioedema (HAE) is an autosomal dominant disease affecting approximately 10,000 people in the United States. HAE causes recurrent attacks of intense localized edema involving the skin, airway, and visceral organs. While chronic therapy with attenuated androgens or plasmin inhibitors has been the mainstay of HAE therapy, many new therapies for prophylaxis and acute treatment are on the horizon. It is important for physicians to understand the signs and symptoms of patients who present with HAE and to be familiar with the conventional and emerging therapies available to treat them.
Peter Werner Christensen, CPIP, Senior Quality Professional with NNE Pharmaplan, and Sam DeMarco, CPIP, President of Compliance Team, Inc., have met the global competency standard and have been conferred the Certified Pharmaceutical Industry Professional (CPIPTM) credential by the ISPE Professional Certification Commission (ISPE-PCCTM).
BioElectronics Corp. (PINKSHEETS: BIEL), the maker of inexpensive, disposable drug-free anti-inflammatory devices, announced the Company is currently preparing an application for 510(k) premarket notification for submission to the Food and Drug Administration (FDA) for general surgical recovery. The filing will request an indication for the adjunct of use in palliative treatment of postoperative edema and pain in superficial soft tissue.
As more specific legislative language emerges on health care, "small business organizations are encouraging members to make their views known through e-mails, letters, phone calls and personal visits" to members of Congress, but "the message is a decidedly mixed one," Kaiser Health News reports. "Small business, a powerful constituency in every congressional district, no longer speaks with one voice on health care. Many of the bigger and more powerful groups that represent small businesses, including the National Federation of Independent Business (NFIB) and the U.S. Chamber of Commerce, have long been allied with Republicans and are lobbying hard against the public option and the employer mandate." But newer, less conservative groups, including the Main Street Alliance, are advocating for those same hot button issues.
"Long second shrift to other medical training, nursing education has taken on new relevance as the country faces a drastic shortage of nurses and a thin job market overall," The Dallas Morning News reports.
The World Food Programme (WFP) issued an urgent appeal on Tuesday for $23 million in "financial support from international donors for food aid to Yemen specifically targeted at women and children," AFP/Google.com reports. The agency said that the "figure represents 42 percent of the 55 million dollars that it needs for the current year to improve the nutrition of more than 1.6 million vulnerable people in Yemen," the news service writes.
Changing Humanitarian Messaging Could Save More People
In research that could lead to new asthma drugs, scientists at Yale School of Medicine, Hydra Biosciences of Cambridge, Massachusetts, and the University of California, San Francisco have discovered that a protein may be a trigger of allergy-induced asthma in mice. They also demonstrated how a drug known to reduce inflammatory and neuropathic pain may also inhibit asthma symptoms in mice. Their paper is published in the May 18-22 online Early Edition of the Proceedings of the National Academy of Sciences.
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Attractive males release fewer sperm per mating to maximise their chances of producing offspring across a range of females, according to a new paper on the evolution of ejaculation strategies. The findings by researchers at UCL (University College London) and the University of Oxford suggest that, paradoxically, matings with attractive males may be less fertile than those with unattractive ones.
Surgeons from Hospital for Special Surgery in New York have identified a drilling technique that improves the outcome of surgery to reconstruct the anterior cruciate ligament (ACL). The news is being presented during the annual meeting of the American Orthopedic Society for Sports Medicine, June 9 -12, in Keystone. Colo.
Lewis Kuller, M.D., Dr.P.H., distinguished professor of public health and professor of epidemiology at the University of Pittsburgh Graduate School of Public Health, has been designated a 2009 American Heart Association Distinguished Scientist for major contributions to cardiovascular disease and stroke research.
Eighty percent of women who have a hysterectomy have a traditional one, in which a surgeon must make an extensive incision that runs from the navel to the top of the pubic bone. If only these women"s gynecologists had been trained in minimally invasive laparoscopic surgery techniques, many of them could have had hysterectomies involving just a few small, keyhole incisions. Also, their recovery time would have also been reduced drastically, permitting them to resume their normal lives much faster.
UroToday.com - Increasingly surgical education is being focused on specific procedural training techniques. These researchers at the University of Minnesota have shown the importance of breaking the procedure down into its specific steps and deconstructing the various tasks applied to each step of the procedure.
The World Health Organization has approved GlaxoSmithKline"s human papillomavirus vaccine Cervarix, thus enabling United Nations agencies and partners to officially purchase millions of doses for use in low-income nations, the AP/San Diego Union-Tribune reports (AP/San Diego Union-Tribune, 7/9). Cervarix is highly effective at preventing HPV types 16 and 18, which cause about 70% of cervical cancer cases (GSK release, 7/9). According to the AP/Union-Tribune, more than 80% of the estimated 280,000 cervical cancer deaths annually occur in developing countries.Cervarix has not been approved for use in the U.S. and Japan, but it is available in 97 other countries. FDA is expected to decide in the next few months whether to approve Cervarix for use in the U.S. (AP/San Diego Union-Tribune, 7/9). The agency in 2006 approved Merck"s HPV vaccine Gardasil for girls and women ages nine to 26. Centers for Disease Control and Prevention guidelines recommend routine three-dose vaccination for girls ages 11 and 12 and for girls and women ages 13 to 26 who have not yet been vaccinated (CDC fact sheet, June 2008).The three-shot regimen typically costs about $360. It is unclear if GSK will provide Cervarix at a lower cost to U.N. agencies purchasing it for developing countries (AP/San Diego Union-Tribune, 7/9). GSK said that it is "eager to work with our long-term partner GAVI as well as other private [non-governmental organizations] or governments of developing countries to identify financing mechanisms for the vaccine" (Stovall, Dow Jones, 7/9). The global health association GAVI is a major buyer of vaccines for the developing world. In 2008, GAVI prioritized the purchase of HPV vaccines for the world"s 73 poorest nations. The organization includes U.N. agencies, the World Bank and the Bill and Melinda Gates Foundation (AP/San Diego Union-Tribune, 7/9).
The U.S. Court of Appeals for the 1st Circuit on Wednesday ruled that a 2007 Massachusetts law requiring antiabortion-rights protesters to stay at least 35 feet away from clinic entrances does not infringe on their free speech rights, the Boston Globe reports. The law updated a 2000 statute that established a floating buffer zone, which police and clinics said was difficult to enforce. The 2007 law set a fixed 35-foot buffer zone around any reproductive health care facility and barred anyone from entering or remaining in the zone unless they work at the clinic; are entering or leaving the facility; are public safety or other municipal officials; or are walking by. Five abortion-rights opponents filed the lawsuit in January 2008. U.S. District Judge Joseph Tauro rejected their claims in August 2008, ruling that the law did not regulate speech -- only the location where the speech could occur -- and that it was drafted in response to safety and law enforcement concerns. The protesters appealed the ruling.The appeals court said that the 2007 law responded to "repeated incidents involving violence and other unduly aggressive behaviors in the vicinity of reproductive health care facilities" and "represents a permissible response by the Massachusetts Legislature to what it reasonably perceived as a significant threat to public safety." The court also said that the law was "content-neutral," as it applies to all protesters regardless of their viewpoints. According to the court, the plaintiffs argued in their appeal that the law had a "content-neutral patina" masking a "more sinister reality" that the Legislature"s true motive was to curb abortion-rights opponents" speech.Massachusetts Attorney General Martha Coakley (D) in a statement said that she was "pleased that the 1st Circuit has upheld this important law, which enhances public safety and access to medical facilities, while preserving the right to engage in expressive activity on public ways and sidewalks near clinics." Tim Chandler, legal counsel for the Alliance Defense Fund, which helped represent the plaintiffs, said abortion-rights opponents "shouldn"t be penalized for expressing their beliefs." He added that the fund and its supporters were evaluating the "next legal step" (Finucane, Boston Globe, 7/10).
President Obama has asked Congress to deliver a bill by October that would "cut healthcare costs and provide medical coverage to most of the 46 million uninsured Americans," a goal that may no longer be realistic as members of the president"s own party move to stall efforts, the Reuters/The Washington Post reports (Allen, 7/9).
Fiscally conservative Democrats in the House are delaying a health care reform bill by withholding their support from it until certain concerns are addressed, the Associated Press reports.
"The Senate dealt a blow to the drug lobby Thursday by voting to permit people in the United States to order lower-cost drugs from Canada over the Internet," the Associated Press/Arizona Republic reports. The drugs in question are often made in the U.S., and then sold abroad for lower prices than at home because because of government policies in many other countries. The bill would make it legal to re-import those drugs more readily. The drug provision passed as an amendment to a Department of Homeland Security funding bill and was introduced by Republican Louisianna Sen. David Vitter (Taylor, 7/9).
The Washington Post reports: "Leaders of the world"s major economies pledged Friday to raise $20 billion over the next three years for food and agricultural aid to the world"s most impoverished countries." According to Obama administration officials, "the U.S. will contribute at least $3.5 billion over the next three years to the worldwide effort," which in addition to the funding, "hopes to better coordinate global food aid efforts and work through initiatives already in place in poor countries around the world, rather than creating new plans," the Washington Post reports (Fletcher, 7/10).
President Obama is expected to arrive in Accra, Ghana, Friday night, the AP/Google.com reports. White House adviser Michelle Gavin said the president chose to travel to Ghana "because it"s such an admirable example of strong, democratic governance, vibrant civil society" (Babington, 7/10). The following are opinion pieces reflecting on his trip and Africa policy:
More and more children are participating and getting hurt playing sports each year. A new study presented at the American Orthopaedic Society for Sports Medicine"s (AOSSM) Annual Meeting in Keystone, Colorado, (July 9-12) details the benefits and risks of repairing a torn anterior cruciate ligament (ACL) in young athletes under the age of 14.
A new study in the Canadian Medical Association Journal (CMAJ) reports that the number of prescriptions in Canada for cardiovascular medications has been increasing over the last ten years. There has been a 200 percent increase in costs. Overall costs of cardiovascular medications exceeded $5 billion in 2006. And statins accounted for nearly 40 percent of the expenditure.
The Union will offer 8 MDR-TB courses in 2009 as part of its commitment to addressing the global increase in multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis.