Medical Devices
According to new research* carried out by Lloydspharmacy, the UK"s leading community pharmacy chain, around 2.1million British holidaymakers and travellers are ignoring the need to protect themselves against malaria.
Evidence suggests that outcomes in many clinical settings leave a lot to be desired, which means that research into quality improvement (QI) in clinical care has the potential to greatly improve the lot of patients. Now a study in the journal Medical Care Research and Review published by SAGE suggests that both theoretical and practical improvements in QI effectiveness studies could make these into much more powerful tools for positive change.
National Community Pharmacists Association (NCPA) Executive Vice President and CEO, Bruce T. Roberts, RPh testified today before the U.S. House Energy and Commerce Subcommittee on Health, offering four different recommendations to strengthen a health care reform proposal currently working its way through Congress.
Bosentan appears to be a more cost-effective initial treatment option for patients with moderate pulmonary arterial hypertension (PAH), classified as WHO functional class III, than no active intervention.
A highly successful and innovative training program that prepares chief residents at medical schools to diagnose and treat health problems common to older adults -- and to prepare the medical students and residents who they help train to do the same -- will include three additional medical schools, the Association of Directors of Geriatric Academic Programs (ADGAP) has announced.
"President Barack Obama on Wednesday rejected the idea of fully taxing Americans" employer-provided health insurance benefits, but suggested he might be persuaded to tax so-called Cadillac coverage ... in the interest of a compromise with Congress," McClatchy/The Star-Telegram reports. The President, speaking at a "town hall-style event" taped at the White House and aired on ABC News, "said he would prefer to pay for expanded coverage by eliminating some deductions for higher-earning taxpayers but that "there"s going to have to be some compromise." The President "said he understands Americans" trepidation about changing the system: "They know that they"re living with the devil, but the devil they know they think may be better than the devil they don"t." He said any reform would be phased in, not happen overnight" (Talev and Lightman, 6/24).
The Massachusetts Department of Public Health yesterday issued a directive recommending that health care providers include written consent for HIV testing in the general permission forms given to patients receiving medical care, the Boston Globe reports. State health care providers typically give patients separate consent forms for HIV testing, a practice health officials say poses as a barrier to HIV testing for patients and their providers. The new Massachusetts recommendation states that HIV testing should be explicitly mentioned on standard general consent forms. Reinforcing a provision in the CDC"s 2006 HIV testing guidelines, the directive also recommends routine HIV testing for all residents age 13 to 64 in health care settings. Patients in Massachusetts must still opt in to HIV testing, whereas the CDC recommends that HIV testing be performed unless a patient opts out, according to the Globe (Cooney, Boston Globe, 6/25).
The New York Times examines a program being offered at an orphanage in Tanzania that provides emotional and physical support for newborns and young children who are at a high risk of death after losing their mothers in infancy. "Africa is full of at least 50 million orphans, the legacy of AIDS and other diseases, war and high rates of death in pregnancy and childbirth," the newspaper writes. "With the numbers increasing every day, Africans are struggling to care for them, often in ways that differ strikingly from the traditional concept of an orphanage in the developed world."
The full U.S. Court of Appeals for the 4th Circuit in a 6-5 decision on Wednesday upheld Virginia"s 2003 law banning what abortion-rights opponents call "partial-birth" abortion, a procedure known medically as intact dilation and extraction, the AP/Hartford Courant reports (O"Dell, AP/Hartford Courant, 6/24). In 2005, a three-judge panel of the U.S. Court of Appeals for the 4th Circuit ruled 2-1 to strike down the Virginia law on the grounds that it does not include adequate exceptions to protect a woman"s health. The U.S. Supreme Court two years ago ordered the appeals court to revisit the issue when it upheld the Partial Birth Abortion Ban Act of 2003, a federal law similar to the Virginia law (White, Washington Post, 6/25). The three-judge appeals panel again struck down the law in 2008 (AP/Hartford Courant, 6/24). The Virginia law permits women to choose various abortion procedures but makes it a crime for providers to perform an intact dilation and extraction, which involves crushing a fetus" skull to ease removal (Washington Post, 6/25). Abortion-rights supporters said that the Virginia law is unconstitutional because its broad definition of intact dilation and extraction could also prohibit standard dilation and extraction, the more common form of second-trimester abortion. Violations of the law would be considered a felony and punishable by up to 10 years in prison. The case is Richmond Medical Center v. Herring (AP/Hartford Courant, 6/24). William Fitzhugh, the Richmond doctor who challenged the Virginia law, said that the banned procedure is necessary to protect the life of the woman in some cases and that the law could prevent abortion providers from performing legal procedures out of fear of prosecution. Stephanie Toti, a Center for Reproductive Rights attorney who represented the plaintiffs, said that the Virginia law is broader than federal law because it punishes abortion providers who accidentally violate the law while performing legal abortion procedures. Judge"s Opinions Judge Paul Niemeyer in the majority opinion wrote that Virginia law protects physicians who are taking needed steps to save a patient"s life and should prevent "a Morton"s fork, where the doctor must choose between criminal liability or care that the doctor believes is not in the best interest of the patient." He added that the circumstances in which doctors could face criminal liability are so limited that they should not invalidate the law in every other case. Judge Blane Michael wrote in the dissenting opinion that the law will create a "real fear of criminal liability" among physicians because it will have the effect of criminalizing the actions of those who seek to perform legal procedures but need to use the banned procedure in rare instances. Michael wrote that the law therefore "places an undue burden on a woman"s right to obtain a pre-viability second trimester abortion -- a constitutional right repeatedly reaffirmed by the Supreme Court" (Washington Post, 6/25).Next StepsToti said that no decision has been made on whether to appeal the decision to the Supreme Court. The Supreme Court"s 2007 decision on the federal law made it clear that abortion bans must include exceptions for the health of the woman, the AP/Hartford Courant reports. Toti said that the appeals court"s decision "just really ignores that precedent." She added, "It"s really insulting to women"s dignity that the court would put so little priority on protecting women"s health and well-being" (AP/Hartford Courant, 6/25). Toti also said, "It puts doctors in a really untenable position because it forces doctors to choose between taking all the steps necessary to protect their patients and committing a felony" (Washington Post, 6/25). Virginia Attorney General Bill Mims said, "While we anticipate that the U.S. Supreme Court may be asked to review the decision, I am confident that the Supreme Court ultimately will uphold the law" (AP/Hartford Courant, 6/25).
FDA on Wednesday approved Watson Pharmaceuticals" generic version of the emergency contraceptive Plan B, the Wall Street Journal reports. The generic drug will be available without a prescription to women ages 18 and older on Aug. 24, when Duramed Pharmaceuticals" market exclusivity for Plan B expires (Kalish, Wall Street Journal, 6/25). The generic version will be available to women ages 17 and younger with a prescription, according to an FDA press release (FDA Web site, 6/24). Watson will market the generic version under the name Next Choice (AP/Washington Post, 6/24).A one-time use pack of the brand-name product, Plan B, currently costs $49.99 through the online retailer DrugStore.com. According to Bloomberg, generic drugs usually cost 30% to 80% less than brand-name versions (Larkin, Bloomberg, 6/24).
The National Institute for Health and Clinical Excellence (NICE) has published final guidance on the use of lenalidomide for multiple myeloma in people who have received at least one prior therapy.
The European Medicines Agency has recommended the first marketing
With the caloric needs of the planet expected to soar by 50 percent in the next 40 years, planning and investment in global agriculture will become critically important, according a new report released recently.
Researchers have discovered a key to the function of a specific protein that helps control the levels of other critical proteins within cells, including a protein that suppresses the spread of cancer. The new information about the mechanism of action of the protein, called gp78, may enable researchers to explore new types of therapies to prevent the spread of cancer. The study, by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, was published in the June 26, 2009, issue of Molecular Cell.
Mice who inherit a particular chromosomal duplication from their fathers show many behaviors associated with human autism, researchers report in the June 26th issue of the journal Cell, a Cell Press Publication. The duplicated chromosomal region in mice is the equivalent of human chromosome 15q11-13, the most frequent cytogenetic abnormality observed in autism, accounting for some five percent of all cases.
The Center for Stem Cell & Regenerative Medicine (CSCRM), comprised of Case Western Reserve University (CWRU), Cleveland Clinic (CC), University Hospitals (UH), and Athersys, Inc. has received 5 million dollars from Ohio"s Third Frontier Commission under the Research Commercialization Program. The funding will help support new and innovative stem cell technologies including two commercial, four emerging and three pilot projects. This funding will be matched by each of the projects to create a $10 million grant benefiting stem cell and regenerative medicine in Ohio.
The NMC announced the appointment of Roger Thompson as its new Director of Standards and Registration.
Researchers at The University of Texas M. D. Anderson Cancer Center have identified a protein that marks the tumor suppressor p53 for destruction, providing a potential new avenue for restoring p53 in cancer cells.
Over the years, research has shown that Latino youth face numerous risk factors when integrating into American culture, including increased rates of alcohol and substance use and higher rates of dropping out of school.
The stomach ulcer bacterium Helicobacter pylori is not transmitted through drinking water as previously thought, but rather through vomit and possibly faeces. This is shown in a thesis at the Sahlgrenska Academy, University of Gothenburg, Sweden. It is therefore possible to prevent the spread of the bacterium in developing countries through some fairly simple measures.
Entomopathogenic fungi may be a safe and efficient means of controlling
Five years from now, Lab scientists will be able to better determine how, when and why plutonium moves in soil and groundwater.
This summer, the University of Rochester"s Mt. Hope Family Center will begin a large-scale, comprehensive study of the effects of child abuse. Funded by the National Institute of Mental Health, the five-year, $2.25 million research project aims to understand how a complex host of factors - from genetics and family environment to hormonal regulation, personality traits, and brain activity - influence the well-being and mental health of children who have experienced child maltreatment.
No time to keep abreast of the most important osteoporosis-related research? Progress in Osteoporosis, the free online journal published by the International Osteoporosis Foundation (IOF) on http://www.iofbonehealth.org/pio provides concise summaries of new research published in the preceding three to four months. The journal is edited by leading osteoporosis researcher and author, Professor Ego Seeman of the University of Melbourne, Australia.
New data demonstrate that treatment with Afinitor® (everolimus) in combination with Sandostatin® LAR® (octreotide acetate suspension for injection) and Afinitor monotherapy may have the potential to stabilise tumour growth in patients with advanced pancreatic neuroendocrine tumours (NET). These results were presented at the 11th World Congress on Gastrointestinal Cancer in Barcelona, Spain.
The national aortic screening programme in the UK should, in due course, prevent about half of all aneurysm deaths in men over 65 and will be extremely cost effective for the NHS, conclude researchers in a study published on bmj.com. However a second study, also published today, concludes that screening is not cost effective and calls for additional research into the long term outcomes and costs of screening.
Health and social care services are overlooking the long-term physical and emotional effects of cancer survivors, leaving many of the two million people living with or beyond the disease in the UK suffering alone and in silence. According to Macmillan Cancer Support, cancer survivors are suffering needlessly and in silence: overlooked by health and social care services that frequently miss the long-term physical and emotional effects of the disease.
The American Public Health Association (APHA) applauds the House for today passing a comprehensive climate change bill that includes important provisions to protect the health of the public.
A nationwide public opinion poll conducted by Hamilton Lock for the British Medical Association released has revealed how worried the public is about future funding of the health service in light of the recession.
Cerebral palsy (CP) is the most prevalent chronic childhood motor disability with an estimated lifetime cost of nearly $1 million per individual. There is evidence that magnesium sulfate (MgSO4) can reduce the incidence of CP for very early preterm infants. Many thousands of pregnant women and their fetuses are exposed to MgSO4 every year in the United States for a variety of indications, and most obstetricians are comfortable with its use. Yet, there is still some controversy over whether magnesium sulfate is truly protective against CP. In three articles published in the June 2009 issue of theAmerican Journal of Obstetrics & Gynecology, the authors shed some light on the debate.
In an unprecedented move today, millions of midwives, nurses and doctors across the world delivered a message to G8 leaders to take urgent action to prevent women dying needlessly in pregnancy and childbirth.
MVP® (Managed Ventricular Pacing), exclusive programming on Medtronic pacemakers, which is proven to be effective in reducing unnecessary pacing in pacemaker patients, was applied in the MVP Trial of implantable cardioverter-defibrillator (ICD) patients. Data from MVP trial, sponsored by Medtronic, Inc. (NYSE: MDT), were presented today as a late breaking clinical trial at Heart Rhythm 2009, the annual scientific sessions of the Heart Rhythm Society.
DOR BioPharma, Inc. (DOR or the Company) (OTC Bulletin Board: DORB), a late-stage biopharmaceutical company, announced that investigators at the Fred Hutchinson Cancer Research Center, Seattle, Washington, published a paper this morning in Bone Marrow Transplantation in which they demonstrate that DOR"s lead product orBec(R) (oral beclomethasone dipropionate or BDP) decreases non-infectious inflammation of the lung in acute gastrointestinal Graft-versus-Host disease (GI GVHD) patients who received allogeneic hematopoietic cell transplants (HCT). Non-infectious inflammation of the lung is a common and potentially fatal complication of HCT that decreases the exchange of oxygen and carbon dioxide between the lung and blood and, in its severe form, may present as interstitial pneumonitis. The full article, entitled "Influence of Oral Beclomethasone Dipropionate on Early Non-Infectious Pulmonary Outcomes after Allogeneic Hematopoietic Cell Transplantation.
Vantia Therapeutics, an emerging pharmaceutical company developing novel, small molecule drugs targeting large, underserved medical markets, announces positive results from a Phase IIa clinical trial of its lead development compound VA106483 for nocturia. The trial showed that oral VA106483 was successful in producing a predictable and sustained anti-diuretic effect in patients, as determined by increased osmolality and decreased urine output. The study also found that VA106483 was generally well tolerated among the patient population.
Sosei Group Corporation ("Sosei"; TSE Mothers Index: 4565) and Vectura Group plc ("Vectura"; LSE: VEC) announce the commencement of a Phase III clinical study by Novartis, with NVA237, a once-daily, long-acting muscarinic antagonist (LAMA) for the treatment of chronic obstructive pulmonary disease (COPD). NVA237 is a dry powder formulation for oral inhalation of glycopyrronium bromide, a LAMA with a rapid onset of activity. The study has now appeared on clinicaltrials.gov and will be recruiting in the next few weeks when the first patient first visit will trigger a $7.5 million milestone payment to both Sosei and Vectura.
Pig heart valves used to replace defective aortic valves in human patients failed much earlier and more often than expected, says a report from cardiac surgeons at Washington University School of Medicine in St. Louis. This is the first report to demonstrate this potential problem, the researchers say.
Melanoma is the most serious form of skin cancer, diagnosed in more than 50,000 new patients in the United States annually. While the rate of incidences continues to rise, survival rate has not improved and the race is on to find the genetic and cellular changes driving melanoma and to devise new means of detection and treatment. In a study published online in Genome Research, scientists have mapped chemical modifications of DNA in the melanoma genome, finding new markers that will help develop more effective treatment strategies to fight this disease.
The high-intensity training undertaken by triathletes has a significant impact on the quality of their sperm, the 25th annual conference of the European Society of Human Reproduction and Embryology heard 29 June. Professor Diana Vaamonde, from the University of Cordoba Medical School, Cordoba, Spain, said that the triathletes who did the most cycling training had the worst sperm morphology.
Despite costs and public skepticism, Democrats are increasingly confident that they"ll enact a vast health care overhaul. McClatchy reports: "The White House is ramping up its behind-the-scenes lobbying of Congress. President Barack Obama is signaling that he could drop some key principles of his campaign if necessary to jump-start negotiations, opening the door to broad tax increases and a plan that could, he now concedes, push people into a government-run insurance program against their will. Senate Democrats also said last week that they were heading toward agreement again after a momentary stall. ... Republicans, too, concede that the Democrats who control Congress and the White House are back on track to push an overhaul into law."
Roll Call reports that "several major industry stakeholders" will be "noticeably absent from the advertising airwaves over the July Fourth recess. Though they will continue to keep in touch with Members through meetings and grass roots, AARP, the American Medical Association, America"s Health Insurance Plans, the Federation of American Hospitals and AdvaMed all say they are sitting out this recess when it comes to advertising campaigns." Senate Finance Chairman Max Baucus, D-Mont., and White House aides have "warned that any groups that run ads attacking reform efforts before the bills have been crafted would lose their seats at the bargaining table," but the "advocacy ad floodgates" may "open shortly." Until then, "groups are working in a lower-profile way to get their messages across to Members," such as planning in-district meetings with Members and activating grassroots networks.
"Major medical organizations are urging health committees in the House and Senate to make comparative-effectiveness research a key component of healthcare reform," Modern HealthCare reports. The Senate Health, Education, Labor and Pension Committee"s bill "plans for a new federal center on health outcomes research was seen by some GOP members as a possible means to ration healthcare." But "a letter, co-signed by the American Medical Association and more than 60 other groups, countered that comparative-effectiveness research would not lead to "cookbook" medicine or rationing of expensive forms of care" (Lubell, 6/26).
The New York Times profiles the Comprehensive Disaster Relief Services (CDRS) hospital in Chikar, Pakistan, which was started by American Todd Shea after the 2005 earthquake in that country. The aspiring musician"s life was turned over to rescue efforts after September 11, when he used his van to "ferry meals to firefighters at Ground Zero," according to the New York Times.
Today, the National Association of Chain Drug Stores (NACDS) and the National Community Pharmacists Association (NCPA) announced their support for H.R. 3108, the Medication Therapy Management Benefits Act of 2009, sponsored by Rep. Mike Ross (D-AR). The bill was introduced on Friday June 26, 2009, and was immediately referred to the Committee on Energy and Commerce and Committee on Ways and Means, two House committees with jurisdiction over comprehensive healthcare reform legislation.
HIV diagnoses among all men in Louisiana declined from 1997 to 2006, but increased in 2007 and 2008 - diagnoses in the New Orleans metropolitan area alone increased by 9 percent from 2007 to 2008, according to the Louisiana Office of Public Health, the New Orleans Times Picayune reports. Of particular concern are the increases among black men in New Orleans. Among black men of all ages, new HIV diagnoses increased by 4 percent from 2007 to 2008, but increased 23 percent for black men age 20 to 24 and 30 percent for those age 45 to 54. The reasons behind the findings are "complex," according to the Times Picayune. Risky sexual behavior, a "declining sense of concern among young people about AIDS and the stubborn cultural stigma of homosexuality in the black community are all believed to be factors," the Times Picayune reports (Sandoval-Griffin, New Orleans Times Picayune, 6/27).
At the annual meeting of the American Optometric Association (AOA), members voted Friday 1,126 to 887 in favor of establishing the American Board of Optometry (ABO) as the entity to develop and implement the framework for board certification and maintenance of certification.
The recent release of two large randomized trials suggests that if there is a benefit of screening, it is, at best, small, says a new report in CA: A Cancer Journal for Clinicians. Authored by Otis W. Brawley, M.D. of the American Cancer Society and Donna Ankerst, Ph.D. and Ian M. Thompson, M.D. of the University of Texas Health Science Center at San Antonio, the review says because prostate cancer is virtually ubiquitous in men as they age, it is clear that a goal of "finding more cancers" is not acceptable. Instead, public health principles demand that screening must reduce the risk of death from prostate cancer, reduce the suffering from prostate cancer, or reduce health care costs when compared with a non-screening scenario. The authors suggest prostate cancer screening has yet to reach one of these standards to date.
The Scottish Government has announced a new approach to the modernisation of community nursing in Scotland, but having listened to the grave concerns of the Royal College of Nursing in Scotland, the specialist skills of health visitors, district nurses and school nurses will not now be lost.
Between the 1932 and 2008 Olympic Games, world record times of the men"s 100m sprint improved by 0.6 seconds due to improved training techniques and technological advances. Imagine if this improvement could be achieved by a simple change in diet. Scientists at the Research Institute of Wildlife Ecology in Austria have managed to achieve an equivalent feat in mice fed on a diet high in polyunsaturated fatty acids.
Every cell lining the small intestine bristles with thousands of tightly packed microvilli that project into the gut lumen, forming a brush border that absorbs nutrients and protects the body from intestinal bacteria. In the June 29, 2009 issue of the Journal of Cell Biology, Matthew McConnell, Matthew Tyska, and colleagues now find that microvilli extend their functional reach even further using a molecular motor to send vesicles packed with gut enzymes out into the lumen to get a head start on breaking down their substrates.
Recommendations for how the HHS Office of the Secretary will spend $400 million in funds for patient-centered research, also known as comparative effectiveness research, were released by Federal Coordinating Council for Comparative Effectiveness Research (CER). The report, mandated by the American Recovery and Reinvestment Act, is designed to help the HHS Secretary and lawmakers improve the quality of care for patients, and provide patients and doctors the best information possible to make decisions about health care.
New HIV therapies have prolonged lives and improved health for patients with HIV, but the treatments have also brought the longer-term effects of the disease into sharper focus.
Speaking at the Annual Conference of the British Medical Association (BMA), Dr Peter Terry, chairman of the BMA Scotland urged MSPs to put party politics aside and stand together to improve health. He also underlined the need for legislation on the price of alcohol as an effective measure to tackle Scotland"s drink problem.
In an effort to increase understanding of the medical device development process and help companies execute the bench-to-bedside process of product development more effectively, researchers at Stanford University have published the first comprehensive model representing the medical device development process.
Tel Aviv University researcher Prof. Noam Eliaz of the TAU School of Mechanical Engineering has developed an electrochemical process for coating metal implants which vastly improves their functionality, longevity and integration into the body.
Scientists have discovered gene expression differences that could lead to better ways to classify, predict outcome, and treat juvenile idiopathic arthritis (JIA). Eventually such findings could enable doctors to target more aggressive treatment to children at risk of more severe arthritis, while those likely to have milder disease could be spared the stronger treatments that carry a greater risk of side effects. The researchers were supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), a part of the National Institutes of Health.
Doctors at the Cedars-Sinai Heart Institute announced today the completion of the first procedure in which a patient"s own heart tissue was used to grow specialized heart stem cells that were then injected back into the patient"s heart in an effort to repair and re-grow healthy muscle in a heart that had been injured by a heart attack.
PROLOR Biotech, Inc. (OTC Bulletin Board: PBTH), formerly Modigene Inc., announced that the U. S. Patent and Trademark Office (PTO) has issued two new patents for the company"s long-acting CTP-enhanced human growth hormone (hGH-CTP) and human erythropoietin (EPO-CTP). The patents cover the composition of PROLOR"s proprietary pharmaceutical compounds as well as certain associated methods. PROLOR"s CTP technology is based on a short amino acid sequence, the Carboxyl Terminal Peptide that occurs naturally in humans. When attached to a therapeutic protein, CTP extends the time that the protein is active in the body.
Otitis media, more commonly known as an ear infection, is the most frequently diagnosed illness in children less than 15 years of age in the United States and is the primary cause for emergency room visits. More than 80 percent of children will experience at least one ear infection before their third birthday. Much research has been dedicated to preventing this common childhood disease at Nationwide Children"s Hospital.
Doctors at a heart center in the US announced yesterday that the first of 24 heart attack patients taking part in a clinical trial has successfully
A new survey from the Stanford University School of Medicine suggests that a significant number of Asian Americans living in California adopt unhealthy sun-exposure behaviors as they become more westernized. The findings underscore a need for increased skin-health awareness on the part of primary care physicians, dermatologists and people of Asian ancestry, who may incorrectly assume that pigmented skin and hair protect against skin cancer.
The General Optical Council (GOC) is today reminding all optical businesses, students and supervisors to ensure their current arrangements for professional supervision of students meet the requirements outlined by the GOC, and examination or assessment bodies. This follows the recent Fitness to Practise (FTP) hearing involving Boots Opticians Ltd (a GOC-registered business); Trevor Burgess, a registered student dispensing optician; and Richard Simmons, a registered dispensing optician.
Being given enough time with a GP and feeling that their problems are taken seriously are the most important factor in patients" satisfaction with their local surgery, according to new data out today. The GP Patient Survey, the biggest healthcare survey of its kind, found that overall satisfaction with surgeries was high at 91%, but there is still room for improvement in accessing GP services, especially getting through on the phone and being able to make appointments more than 48 hours in advance.
Inovio Biomedical Corporation (NYSE Amex: INO), a leader in DNA vaccine design, development and delivery, announced today it has established a new collaboration with the National Microbiology Laboratory of the Public Health Agency of Canada and the University of Pennsylvania to further evaluate Inovio DNA vaccine candidates against swine influenza A (H1N1) virus. As a part of its universal influenza vaccine program, Inovio has designed and manufactured consensus DNA vaccines for H1N1 influenza strains. These consensus vaccines, delivered using Inovio"s proprietary electroporation technology, have the potential to provide protection against a broad scope of existing as well as currently unknown, unmatched influenza strains that could emerge -- one of the perpetual challenges in trying to protect against influenza. The purpose of this collaboration is to test these vaccine candidates against pandemic and seasonal influenza strains in animal models and will include testing against a recently identified swine H1N1 strain.
PPD, Inc. (NASDAQ: PPDI) today announced that Takeda Pharmaceutical Company Limited issued a news release reporting that Takeda Global Research & Development Center, Inc., its wholly-owned U.S. subsidiary, has received a complete response letter from the U.S. Food and Drug Administration (FDA) regarding its new drug application (NDA) for alogliptin.
CytRx Corporation (NASDAQ: CYTR), a biopharmaceutical research and development company engaged in the development of high-value human therapeutics, provided a favorable progress update for its ongoing Phase 2 STAR-1 registration clinical trial to evaluate the efficacy and safety of orally administered tamibarotene as a third-line treatment for acute promyelocytic leukemia (APL).
Teva Pharmaceutical Industries Ltd. (Nasdaq: TEVA) and its partner, Antares Pharma, Inc. (NYSE Amex: AIS) announced the approval of a Supplemental New Drug Application (sNDA), which added "needle-free injection" to its Tev-Tropin® [somatropin (rDNA) for injection] brand human growth hormone (hGH) drug label. Teva will market the Antares needle-free device as the Tev-Tropin Tjet Injector system.
The following summarizes selected women"s health-related blog entries. ~ "Just Released: Gains and Losses for Women in 2008-09 Supreme Court Decisions," National Women"s Law Center"s "Womenstake": The Supreme Court"s 2008-2009 term, which concluded Monday, included "several crucial decisions that demonstrate the impact of the court on women"s lives," according to the blog post, which summarizes a new analysis from NWLC on the cases. For example, the blog post says that the rulings in Fitzgerald v. Barnstable School Committee and Crawford v. Metropolitan Government of Nashville and Davidson County, Tenn., increased employees" protections against discrimination in the workplace. However, the rulings in Ricci v. DeStetano -- which overturned an appellate court"s anti-discrimination ruling -- and AT&T Corp. v. Hulteen -- which "permitted AT&T to pay women lower pension benefits for the rest of their lives" -- were "not as positive," the blog entry says. NWLC Co-President Marcia Greenberger said that the Supreme Court "ignored the realities of the workplace and the intent of Congress and ruled against female workers" in AT&T v. Hulteen. Greenberger also said that such cases "underscore why every seat on the Supreme Court is of paramount importance to women," adding that it is "absolutely critical" that Supreme Court nominees have "a strong commitment to upholding and enforcing women"s basic legal rights and protections" ("Womenstake," National Women"s Law Center, 6/29).~ "Waldman and Saletan: Oh What a Fine Bromance!" Jodi Jacobson, RH Reality Check: In a recent bloggingheads.tv chat on "common ground" in the abortion-rights debate, Slate columnist Will Saletan and Beliefnet Editor-in-Chief Steve Waldman "spent as much time as possible complimenting each other"s work" and "as little as possible on any real substance regarding reproductive health and choice issues," Jacobson writes. It is "clear that the Obama administration"s stated intention to create "a common ground platform"" on abortion rights has become "a full employment program for both Waldman and Saletan," she writes. Jacobson continues, "So perhaps the most striking thing about the conversation was that, in the end, they both effectively concluded that the common ground enterprise was a "just for show" political strategy," and that the "real strategies" necessary to reduce the need for abortion "are the very prevention programs least likely to be supported by the far right. (Revelation!)." She adds, "However, they came to this conclusion through the same faux-expert uninformed arguments that characterize their columns." During the "Will-interviews-Steve format," Saletan "revealed once again that there is no core philosophy or framework underlying his ever-shifting positions on choice and abortion," according to Jacobson. She adds that "Waldman, for his part, several times underscored what is clear from reading his work": that he "just throws things "out there" without considered thought" about what "might be good versus bad data, not understanding how to read evidence," and "oblivious or uncaring about the effects his free-form moralistic misinformation and opinions might actually have on an already polarized debate." According to Jacobson, "Public policies affecting sexual and reproductive health issues" should be "based first and foremost on public health and on promoting individual rights balanced by individual responsibilities," but "as anyone living on Planet Earth knows, sex and reproduction have become the front in a war waged by ultra-conservative religious and political forces for which Waldman serves as a paid flacky." She continues, "In fact, Waldman himself stated during the program: "I have a corporate interest in injecting religion into every debate."" Jacobson states, "Reading and watching this duo is like buying the OK! magazine version of the culture wars at the grocery store; they put whatever sells on the front cover, no matter the truth or consequences.
"Crunching data from published studies, the authors found that treating a lung-cancer patient with Erbitux, a drug that costs $80,000 for an 18-week regimen, prolongs survival by only 1.2 months," the Wall Street Journal reports. The study, which estimates that the life of each American who dies or cancer could be extended by one year at the cost of $440 billion, was published in the Journal of the National Cancer Institute.
Pharmacists Need A Place At The Health Reform Table The Baltimore Sun
GPs and practice managers still face familiar barriers when it comes to making one of the government"s flagship health policies a success, yet many remain optimistic that practice-based commissioning (PBC) can make a difference to patient care.
The British Medical Journal examines the outcome of the Drugs for Neglected Diseases initiative meeting held in Nairobi, Kenya, last week. More than 200 international health experts came together to discuss finding therapies for such diseases as visceral leishmaniasis, Chagas disease and sleeping sickness. "Current treatments are often toxic, prohibitively expensive, or difficult to administer in countries with limited res," and "[d]rug companies have little incentive to develop treatments for neglected diseases that mainly affect poor people," the journal writes.
Boston Globe columnist Derrick Jackson examines why some Ugandans do not support indoor spraying of DDT to prevent malaria. Grace Kagoro, a biology professor and environmental researcher at Mbarara University of Science and Technology, is "nervous about adding what she said could be one more shock to the soil and water," according to Jackson.
A recent court decision in Black Hawk County, Iowa where a 34-year-old HIV-positive man was sentenced to 25 years in prison and a lifetime of parole for not informing a sexual partner of his status, might lead to a national discussion on state criminal transmission laws, the Iowa Independent reports. Nick Clayton Rhoades pleaded guilty to criminal transmission of HIV, a felony in Iowa, although he did not transmit the virus to his partner. Under state law, "in direct contradiction to its formal title," transmission is not required for a person to be prosecuted - engaging in activity that intentionally exposes others to the body fluids of an infected person could result in prosecution, including kissing, according to the Independent. Some say that such unintended consequences might encourage Iowa and other states to revisit their transmission laws, the article states (Waddington, Iowa Independent, 6/29).
Responding to the publication of Lord Darzi"s report, High Quality Care for All: Our Journey So Far, Dr Peter Carter, Chief Executive & General Secretary of the Royal College of Nursing (RCN), said:
The nation"s largest veterinary association applauded four members of the U.S. House of Representatives for introducing legislation that confronts public health threats by investing in the public health veterinary workforce
Daily sex (or ejaculating daily) for seven days improves men"s sperm quality by reducing the amount of DNA damage, according to an Australian study presented to the 25th annual meeting of the European Society of Human Reproduction and Embryology in Amsterdam.
One-step screening for both genetic and chromosomal abnormalities has come a stage closer as scientists announced that an embryo test they have been developing has successfully screened cells taken from spare embryos that were known to have cystic fibrosis.
An observer feels more empathy for someone in pain when that person is in the same social group, according to new research in the July 1 issue of The Journal of Neuroscience. The study shows that perceiving others in pain activates a part of the brain associated with empathy and emotion more if the observer and the observed are the same race. The findings may show that unconscious prejudices against outside groups exist at a basic level.
While major advances have been made in the understanding of posterior cruciate ligament (PCL) anatomy and reconstruction, a literature review published in the July 2009 issue of the Journal of the American Academy of Orthopaedic Surgeons (JAAOS) finds that there must be continued advances in basic science research in order to determine the best course of treatment for those with PCL injuries.
As scientists continue to decode the human genome and the information becomes publicly available, private companies that offer online genetic testing are multiplying. Scientists at the National Institutes of Health were concerned that perhaps these tests posed a risk.
Researchers have found that men and women who feel sensitive to rejection based on their physical appearance are more likely to express interest in having cosmetic surgery than those who are less sensitive to appearance-based rejection. This effect is particularly true when people recall negative comments about their physical appearance.
Researchers at the Sahlgrenska Academy, Gothenburg, have discovered a new brain mechanism involved in alcohol addiction involving the stomach hormone ghrelin. When ghrelin"s actions in the brain are blocked, alcohol"s effects on the reward system are reduced. It is an important discovery that could lead to new therapies for addictions such as alcohol dependence.
A novel vaccine strategy using virus-like particles (VLPs) could provide stronger and longer-lasting influenza vaccines with a significantly shorter development and production time than current ones, allowing public health authorities to react more quickly in the event of a potential pandemic.
The Met Office has raised the heatwave warning alert again today on behalf of the Department of Health.
Doctors have reaffirmed their opposition to assisted suicide following a debate at the BMA"s Annual Conference in Liverpool yesterday. Doctors rejected calls from Thameside doctor, Kailash Chand to change legislation to allow the choice of an assisted death by patients who are terminally ill and who have mental capacity.
AMAG Pharmaceuticals, Inc. (NASDAQ:AMAG) announced that the U.S. Food and Drug Administration (FDA) has granted marketing approval for Feraheme™ (ferumoxytol) Injection for intravenous (IV) use as an iron replacement therapy for the treatment of iron deficiency anemia in adult patients with chronic kidney disease. The recommended dose of Feraheme is an initial 510 mg IV injection followed by a second 510 mg IV injection three to eight days later. Feraheme should be administered as an undiluted IV injection delivered at a rate of up to 1 mL/sec (30 mg/sec). The recommended Feraheme dose may be readministered to patients with persistent or recurrent iron deficiency anemia.
Despite rapid advances using a child"s own cord blood stem cells in regenerative therapies to repair damaged tissue due to injury or disease, most pregnant women today don"t learn about the ability to save their newborn"s cord blood. According to research published in the Journal of Reproductive Medicine, 3 out of every 4 pregnant women consider themselves only "minimally informed."
Because females carry two copies of the X chromosome to males" one X and one Y, they harbor a potentially toxic double dose of the over 1000 genes that reside on the X chromosome.
In a first-of-its-kind advance toward the next generation of genetically modified foods - intended to improve consumers" health - researchers in Japan are reporting that a new transgenic rice designed to fight a common pollen allergy appears safe in animal studies. Their report is in the current issue of ACS" Journal of Agricultural and Food Chemistry, a bi-weekly publication.
British scientists have found a significant link between later retirement age and later onset of dementia in men.
The California Medical Association announced it is endorsing propositions 1A, 1B and 1C in the statewide special election on Tuesday.
There is growing evidence that a procedure for identifying chromosomal abnormalities in embryos prior to in vitro fertilization is ineffective at helping older women become pregnant, the Wall Street Journal reports. The procedure -- known as pre-implantation genetic screening, or PGS -- is performed in dozen of U.S. fertility clinics and sometimes marketed to older women as a way to increase the odds of a healthy live birth. PGS involves extracting a single cell from a six-cell embryo and inspecting it for chromosomal abnormalities known as aneuploidies; unaffected embryos can then be implanted through IVF. Women older than age 35 have a higher risk of aneuploidies, in which embryos have fewer or more than the usual number of 23 pairs of chromosomes. Aneuploidies can trigger early miscarriage or certain genetics conditions, such as Down syndrome. Most medical experts agree that embryo screening is capable of significantly reducing the risk of Down syndrome and other serious chromosome-related illnesses. However, evidence from several studies increasingly suggests that the procedure does not increase older women"s chances of healthy live births. The American Society for Reproductive Medicine released an initial opinion about PGS in 2007, saying that available evidence does not support the use of embryo screening to increase live birth rates in older women. Andrew La Barbera, scientific director of the society, said, "Since that time, there have been several more trials that have reached the same conclusion." Another shortcoming is that most clinics can only test for fewer than half of the 23 chromosomes, meaning that many defects can go undetected. However, medical experts say that the use of PGS has increased in the two years since ASRM issued its recommendations. According to the Journal, PGS can add more than $2,000 to the roughly $10,000 cost of one IVF cycle. Very few health insurers cover PGS, though some pay for IVF. Some experts contend that studies showing a lack of clinical benefit from PGS do not use more efficient biopsy techniques that can prevent damage to the embryo. Santiago Munne, scientific director for Reprogenetics, said that the treatment is "effective." In a 2007 study, Munne and colleagues used PGS to reduce the rate at which patients miscarried. However, the chances of a woman getting pregnant largely were unchanged, which the authors said could be attributed to the small number of study participants (Naik, Wall Street Journal, 6/1).
"As details emerge of the pharmaceutical industry"s agreement to kick in $80 billion to help pay for health care reform, the deal is facing increasing skepticism from inside and outside the health care industry," Politico reports.
Comparative-Effectiveness Research - Implications of the Federal Coordinating Council"s Report The New England Journal Of Medicine
More than fifty institutions from eighteen African countries - from Senegal to Sudan to South Africa - are to participate in international consortia under a ÷£30 million initiative from the Wellcome Trust to strengthen research capacity on the continent.
The 2009 Neuroscience Prize of The Peter and Patricia Gruber Foundation is being awarded to Jeffrey Hall, professor of neurogenetics at the University of Maine; Michael Rosbash, professor and director of the National Center for Behavioral Genomics at Brandeis University; and Michael Young, professor and head of the Laboratory of Genetics at Rockefeller University. On October 18, at the annual meeting of the Society for Neuroscience in Chicago, Illinois, these three distinguished scientists will receive this prestigious international award for their groundbreaking discoveries of the molecular mechanisms that control circadian (daily) rhythms in the nervous system. Their research was the first to establish a simple relationship between single genes and a complex behavior.
A human growth factor that stimulates blood stem cells to proliferate in the bone marrow reverses memory impairment in mice genetically altered to develop Alzheimer"s disease, researchers at the University of South Florida and James A. Haley Hospital found. The granulocyte-colony stimulating factor (GCSF) significantly reduced levels of the brain-clogging protein beta amyloid deposited in excess in the brains of the Alzheimer"s mice, increased the production of new neurons and promoted nerve cell connections.
Liver transplantation offers a good chance for survival for patients with drug induced acute liver failure, however, certain pre-transplant factors are associated with worse outcomes. Patients who are on life support, who have elevated serum creatinine, and children whose liver failure was caused by antiepileptic drugs did not fare as well after transplantation. These findings are in the July issue of Liver Transplantation, a journal published by John Wiley & Sons. The article is also available online at Wiley Interscience.
Illinois Department of Public Health Director Dr. Damon T. Arnold wants to remind you of some steps you can take to ensure a safe and healthy Fourth of July.
Counseling patients with non-alcoholic fatty liver disease (NAFLD) on how to increase physical activity leads to health benefits that are independent of changes in weight. These findings are in a new study in the July issue of Hepatology, a journal published by John Wiley & Sons on behalf of the American Association for the Study of Liver Diseases (AASLD). The article is also available online at Wiley Interscience.
Cases of the 2009 H1N1 influenza A virus has been confirmed in a Crawford County adult and a Miami County child. These are the first cases identified in both counties.
New research at Rhode Island Hospital has uncovered the biological effects of a novel membrane estrogen receptor, a finding that has potential implications for hormonal therapy for breast cancer. The study is published in the July edition of the journal Molecular Endocrinology. This new study by Edward Filardo, MD, and his research team further supports earlier published work by the group that linked the transmembrane receptor, GPR30/GPER-1, to specific estrogen binding, rapid estrogen signaling and breast cancer metastasis. "What is exciting about this new work," says Filardo, "is that it provides some insight into the influence of GPR30 at the cellular level. It shows that estrogen action through GPR30 allows for breast tumor cell survival, and not breast tumor cell proliferation." Prior studies by Filardo"s group showed that estrogen acts through GPR30 to promote the rapid release of preformed growth factors that are tethered to the surface of breast cancer cells. Their latest study was conducted in an effort to better understand the mechanism by which GPR30 triggered the release of epidermal growth factor (EGF) polypeptides from the surface of breast cancer cells.
Dartmouth researchers have determined that movie characters who smoke, regardless of whether they are "good guys" or "bad guys," influence teens to try smoking. The study, published in the July 2009 issue of the journal Pediatrics, is titled "Adolescent Smoking: Who Matters More, Good Guys or Bad Guys?"
The American Dietetic Association has released an updated position paper on vegetarian diets that concludes such diets, if well-planned, are healthful and nutritious for adults, infants, children and adolescents and can help prevent and treat chronic diseases including heart disease, cancer, obesity and diabetes.
The second of two reviews in this week´s The Lancet discusses the primary origins of the health gap. In an effort to understand these inequalities, the authors attempt to give an Indigenous perspective. It is the work of Professor Malcolm King, of the University of Alberta, Edmonton, Canada, and Scientific Director, Institute of Aboriginal Peoples" Health (Canadian Institutes of Health Research); Dr Alexandra Smith, of the University of Toronto, Canada; and Professor Michael Gracey, Unity of First People of Australia, Perth, Australia. In this review, the authors focus on North American Indigenous groups, although others are discussed.
This statement updates Members on the Influenza A (H1N1) swine flu outbreak and the latest developments in Wales, across the UK and internationally.
Some Iowa groups are concerned that the state"s criminal HIV transmission law adds to the stigma associated with the virus and hampers testing efforts, and are urging lawmakers to revisit the law, the Iowa Independent reports. According to the Independent, criminal transmission of HIV is classified among the second-most serious felonies that can be committed in the state. Those that have been convicted under the law have been sentenced to a few months to several decades in prison. Former state Rep. Ed Fallon (D) who supported the 1998 law, said, "It seems to me that since it is now 11, almost 12, years later, it wouldn"t be [a] bad time to take a look at it again," adding that "surely [there] are some tweaks or changes that the legislature could consider relevant to this law, especially with all the new knowledge we have of the disease" (Waddington, 7/1).
An OECD report has confirmed that GP-led primary care is a cost effective way to promote good health while sending a warning about the need to better promote general practice as a career. The OECD Health Data 2009 report says despite the growing need for GPs worldwide there is an increasing trend towards specialisation. The number of specialists rose by 60% between 1990 and 2007, compared with only a 23% increase in GPs.
This week Nursing Standard published some misleading and speculative information regarding the NMC"s registration fee. The story, titled "Registration fees could increase as regulator goes into black", also included factually inaccurate information about the NMC"s diversity data collection exercise which will soon be launched.
President Barack Obama pitched his health reform proposal Wednesday at a town hall meeting in Annandale, Va., asking the public and Congress to deliver on health care reform.
Home remains the likeliest place to suffer an eye injury, according to a survey conducted by the American Academy of Ophthalmology (Academy) and the American Society of Ocular Trauma (ASOT). The annual Eye Injury Snapshot, a clinical survey of eye injuries across the U.S., conducted from May 17 to May 24 this year, found that nearly half (47.6 percent) of the 2.5 million eye injuries that Americans suffer annually now happen in and around the home in common places like the lawn, garden, kitchen or garage.
"A new large-scale study of medical records found that the extra cost of extending prescription coverage to Medicare enrollees was substantially offset by lower spending on other medical care for people who previously had limited or no prescription-drug coverage," The Wall Street Journal reports.