Mental Health
Living in an area with more fast food outlets and convenience stores than supermarkets and grocers has been associated with obesity in a Canadian study. Researchers writing in the open access journal BMC Public Health have shown that your local food environment can affect your weight.
Researchers have identified a new candidate tumor suppressor gene in colorectal cancer and examined its use as a potential biomarker in stool samples, according to a new study published online June 17 in the Journal of the National Cancer Institute.
In research that could lead to new approaches for the treatment of type 2 diabetes, a Yale School of Medicine team has found that suppressing a liver enzyme that induces glucose production helped diminish the symptoms of the disease in a rat model - reducing blood glucose concentrations, decreasing rates of glucose production in the liver, and improving insulin sensitivity. Decreasing expression of the gene, Sirtuin 1, also lowered total cholesterol levels.
A new landmark collaboration between the Global Alliance for TB Drug Development (TB Alliance), a not-for-profit, product development partnership, and Tibotec Inc., (Tibotec), a global pharmaceutical company, has been announced at the Pacific Health Summit in response to the urgent need to accelerate the discovery and development of new drugs to fight tuberculosis (TB).
Health officials said on Thursday that it looks like the novel H1N1 swine flu virus will continue to spread in the US through the summer months,
Researchers found support for an association between the use of stimulants and sudden unexplained death among children and adolescents, according to a study released today by The American Journal of Psychiatry.
NHS Barking and Dagenham and HIV and sexual health charity Terrence Higgins Trust (THT) have achieved a national target by encouraging over 17% of under-25s in the region to test for the sexually transmitted infection (STI) chlamydia. To tackle chlamydia in the area, more young people need to come forward for testing and continue testing on a regular basis - the target for 2009/2010 is 25%.
"It was particularly devastating on Wednesday when [Sen. Orrin Hatch, R-Utah]" - a longtime friend of Sen. Edward Kennedy, D-Mass., - "warned Democrats on the panel that they have already made some grave errors in their effort to write legislation overhauling the health care system," reports the New York Times in The Caucus Blog. "Now unfortunately we are beginning a partisan exercise on perhaps the most important legislation of our lives," Hatch said during a meeting of the Senate Health, Education, Labor and Pensions Committee yesterday (Herszenhorn, 6/17).
The Wall Street Journal/Dow Jones Newswires reports on reaction to the Obama administration"s proposed cuts that may acutely affect hospitals. It notes: "President Obama last weekend called for $313 billion in savings over 10 years through adjustments in Medicare and Medicaid payments - a plan that a "deeply disappointed" American Hospital Association said would mean $220 billion in payment cuts to hospitals, on top of billions in other proposed Medicare cuts."
Rural Solutions, an organization in northeast Colorado, held the "Community HIV/AIDS Education and Action Conference" as part of its ongoing effort to address issues related to HIV, the Sterling Journal-Advocate reports. At the conference, the organization presented the results of a recent needs assessment of HIV/AIDS services in the northeastern part of the state - conducted in partnership with the Center for Research Strategies and funded through the Colorado Department of Public Health and Environment - which found that HIV prevention services in the area are limited; barriers exist for HIV testing including confidentiality and costs; and mental health and substance use services for at-risk people also are limited, according to the Journal-Advocate (Jones, Sterling Journal-Advocate, 6/17).
The European Congress on Anti-Aging & Aesthetic Medicine (ECAAAM) is proud to welcome the support of the University of Mainz for its 2nd annual event (15th - 17th October, Mainz, Mainz Congress Centre). ECAAAM is a cutting edge congress that provides medical professionals, scientists and industry personnel with the training and education they need to treat age-related dysfunctions, disorders and diseases.
The Autism Bill is back in Parliament for its third reading today. Having secured the Government"s support it is expected to pass to the House of Lords where it will be well on its way to becoming England"s first disability-specific law.
Some parents may be unnecessarily switching infant milk formulas for their healthy infants. A study published in BioMed Central"s open access Nutrition Journal, found that many parents misinterpret common baby behaviors as milk intolerance and needlessly switch formulas without consulting a health professional.
Light touch - the sense that lets musicians find the right notes on a keyboard, a seamstress revel in the feel of cool silk, the artisan feel a curve in material and the blind read Braille - truly depends on the activity of Merkel cells usually found in crescent-shaped clusters in the skin, said researchers from Baylor College of Medicine and colleagues in a report that appears in the current issue of the journal Science.
Researchers have made progress in developing malaria vaccines over the past few decades, but the goal remains a daunting challenge. Malaria has evolved to thwart almost every aspect of the human immune system. On March 16-17, 2009, the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, convened a workshop to encourage more immunologists to enter malaria research and to foster scientific collaborations that may help lead to the development of effective malaria vaccines. The proceedings of that meeting are in the July 2009 issue of Nature Immunology, and available online June 18.
Inspired by the behavior of the human eye, Boston College computer scientists have developed a technique that lets computers see objects as fleeting as a butterfly or tropical fish with nearly double the accuracy and 10 times the speed of earlier methods.
Dr. Denis Therien, Vice-Principal (Research and International Relations) of McGill University has welcomed the Canada Foundation for Innovation"s (CFI) investment of $32,649,184 supporting five projects led by Dr. David Plant, Dr. Paul Lasko, Dr. David Thomas, Dr. Vincent Giguç¨re and Dr. Chao-Jin (C.J.) Li. The Quebec government also confirmed it would match that funding.
Allergy testing and treatment may offer a new therapeutic option for many patients with interstitial cystitis (IC). IC is a severely painful bladder condition affecting as many as 8 million women and 1.5 million men in the United States. Patients and the providers who treat them have long noticed a correlation between allergies and IC. Recently, a urologist and allergist in Louisville, Kentucky, began to explore the link between these two chronic ailments to provide patients with more effective treatment. The story of their discoveries is featured in the ICA Update, the quarterly magazine of the Interstitial Cystitis Association (ICA).
Human Genome Sciences, Inc. (Nasdaq: HGSI) announced that Novartis has completed enrollment and initial dosing in a Phase 2b clinical trial to evaluate the safety and efficacy of Albuferon(R) (albinterferon alfa-2b) administered monthly in combination with ribavirin in treatment-naive patients with genotypes 2 and 3 chronic hepatitis C. Albuferon is being developed by HGS and Novartis under an exclusive worldwide co-development and commercialization agreement entered into in June 2006.
Congress can help diminish barriers to quality care for people with serious illness, according to Howard Tuch, MD, MS, a spokesperson for the American Academy of Hospice and Palliative Medicine (AAHPM). AAHPM was one of three groups that presented information at a Capitol Hill briefing coordinated by the offices of US Reps. Earl Blumenauer and Charles Boustany, MD, sponsors of legislation (HR 1898) that would provide Medicare coverage for "end of life" care consultations.
Accuray Incorporated (Nasdaq: ARAY), a global leader in the field of radiosurgery, announced that the Turkish Ministry of Health has purchased two CyberKnife(R) Robotic Radiosurgery Systems for installation in Ankara and Istanbul, Turkey.
TranSenda International, LLC announced today that it is developing a new solution, Cortex, designed to improve an organization"s ability to manage a clinical trial"s performance. Based upon patent-pending ClinBUS® data interchange technology already in use in TranSenda"s Office-Smart solutions, Cortex will enable organizations to leverage the power of access to centralized operational data from all applications used across all clinical studies. For years the industry has struggled with an increasingly fragmented environment of disconnected clinical applications, sites and partners. TranSenda"s Cortex, with its proven ClinBUS technology, represents a breakthrough in managing and controlling studies within a common environment-independent of study data formats and clinical trial applications.
Seattle Genetics, Inc. (NASDAQ:SGEN), announced that it has initiated a phase II clinical trial of SGN-35 for patients with relapsed or refractory systemic anaplastic large cell lymphoma (ALCL). SGN-35 is an antibody-drug conjugate (ADC) that utilizes Seattle Genetics" proprietary technology to empower antibodies by linking them to potent cell-killing drugs.
Indigenous people in the Northern Territory who participate in "caring for country" activities enjoy significantly better health, a study published in the May 18 Indigenous Health issue of the Medical Journal of Australia has found.
UroToday.com - Men undergoing surgical interventions for BPH are still at risk for subsequent development of prostate cancer (CaP) due to residual tissue. It is suggested that PSA decreases approximately 0.1-0.3ng/ml for every 1g of prostate tissue removed. In the online edition of Urology, Dr. Brian Helfand and associates determined the PSA values and PSAV in patients who had undergone TURP, holmium laser resection of the prostate (HoLRP), or open prostatectomy (OP) for treatment of BPH and compare these values in patients with histologic BPH only with the values in those with incidentally found CaP.
UroToday.com - Insufficient intake of zinc (Zn) can impair antioxidant defenses and may be an important risk factor in oxidant release, compromising the mechanism of DNA repair, and making the sperm cell highly susceptible to oxidative damage. In the absence of Zn, the possibility of increased oxidative damage exists that would contribute to poor sperm quality. Infertile men and men who smoke are very susceptible to oxidative damage induced by free radicals. In the present study, we hypothesized that major changes in the level of seminal Zn levels are related with low quality of sperm and poor fertilizing capacity.
Women are under too much pressure to lose weight quickly after giving birth, according to German Institute
More than 80% of hospitals across the U.S. have implemented automated dispensing cabinets (ADCs) as an important part of their drug distribution system, making the evaluation of practices and policies surrounding this technology an essential step in ensuring patient safety. To help meet healthcare organizations" growing need for assistance in this area, the Institute for Safe Medication Practices (ISMP) has introduced the first Medication Safety Self Assessment® for Automated Dispensing Cabinets.
Health and Human Services Secretary Kathleen Sebelius, spoke to The New York Times about the state of health care reform on Capitol Hill during a 15-minute interview.
The Slow, Slow Pulse Of The Deliberative Body The Washington Post
As part of an effort to encourage Staten Island, N.Y., residents to be tested for HIV, the CARE Network, the Black Leadership Commission on AIDS and the City Council"s Communities of Color Faith Initiative, have partnered to launch the "Staten Island HIV Status Check Campaign," the Staten Island Advance reports. "Status Check" postcards that include information on free local HIV testing locations, HIV educational literature and condoms will be distributed by local organizations and businesses as part of the initiative. The goal is to reach the 56 percent of local residents who have never been tested for HIV, Karina Ryan, CARE Network coordinator, said (Slepian, Staten Island Advance, 6/18).
The Economist examines schistosomiasis in China. The disease, which is also called snail-fever, is the "world"s second-most prevalent tropical disease after malaria, affecting 207 million people of whom 726,000 are Chinese, according to the most recent official figures, from 2004," the Economist reports.
Oculus Innovative Sciences, Inc. (Nasdaq: OCLS), a healthcare company that develops, manufactures and markets a family of products based upon the Microcyn® Technology platform, announced that preliminary results from its U.S. 40-patient feasibility study, in which an enhanced formulation of the company"s Microcyn Technology-based hydrogel was used in the treatment of acne, are highly encouraging and warrant further examination.
After years of declining teenage pregnancy rates and improved teen contraception use during the 1990s and early 2000s, the trends appeared to have flattened or even reversed among some groups of teens in recent years, according to a study from Columbia University"s Mailman School of Public Health and the Guttmacher Institute, the Christian Science Monitor reports. Researchers found that from 2003 to 2007, teens" contraceptive use declined by 10%, while their level of sexual activity did not change. The decrease in contraceptive use was particularly prevalent among black teens. The figures take into account the rate of contraception use as well as the types of contraceptives used, as methods vary in effectiveness. Teen condom use leveled off and in some cases declined, according to the study. The study also reported that the teen birth rate increased by 5% from 2005 to 2007. According to the study"s authors, the findings suggest a link between declining teen contraception use and the rise in abstinence-only education during former President George W. Bush"s administration. President Obama"s fiscal year 2010 budget proposal calls for redirecting some abstinence-only funds toward increased comprehensive sex education, the Monitor reports. In addition to the effects of abstinence-only sex education, the decline in condom use also could be tied to lessening concern about sexually transmitted infections, including HIV/AIDS. A shift in the teen population to include a higher number of Hispanics -- who have the highest rates of teen pregnancy and birth -- also could contribute to the findings. Laura Lindberg, one of the study"s authors and a senior research associate at Guttmacher, said, "In the end, this story is really about the loss of momentum." She added that although the statistical changes are small, "they raise concern about what the next few years will bring in this country." Sarah Brown, director of the National Campaign To Prevent Teen and Unplanned Pregnancy, noted that the proportion of births to unmarried women, particularly among women ages 20 to 24, also is on the upswing (Feldmann, Christian Science Monitor, 6/18).
There were nearly 158,000 potentially avoidable childbirth-related injuries to women and their infants in 2006, a significant decline from 2000, according to a report by the Agency for Healthcare Research and Quality, HealthLeaders Media reports. The report used data submitted for 15 million discharges by 1,900 hospitals in 25 states, including the largest states -- California, New York, Florida and Texas. Between 2000 and 2006, the rate of potentially avoidable injuries during vaginal childbirth without the use of instruments, such as forceps, declined by 30%, according to the report. The injury rate declined by 21.3% for vaginal childbirth using instruments and by 16.7% for women undergoing caesarean sections. Report author Roxanne Andrews of AHRQ said that the report did not examine factors that might have contributed to the declining injury rates but added that it is an area for further study.The report found that rates of injury were higher when instruments were used during childbirth. For instance, trauma to the woman during vaginal delivery with the use of instruments occurred 160.5 times per 1,000 discharges, compared with 36.2 times when instruments were not used. The report said that the most common injuries to women were perineum tears, which are avoidable in many cases. Traumatic injury to infants during childbirth -- such as broken collarbones, head injuries and infections -- occurred 1.6 times per 1,000 discharges.The report also highlighted care disparities between women in low-income areas and those in high-income areas. Women giving birth in high-income areas had 44% more injuries during vaginal delivery than their counterparts in low-income areas. Black and Hispanic women experienced fewer injuries than white women, while Asian American and Pacific Islander women experienced the highest rate of injuries. The report found that women covered by Medicaid were less likely to be injured during childbirth -- 127 injuries per 1,000 deliveries -- compared with women with private insurance plans -- 185 injuries per 1,000 deliveries. However, the rate of injury for infants covered under Medicaid was higher -- 1.7 per 1,000 deliveries -- than those under private plans -- 1.5 per 1,000 deliveries.The report encouraged providers to evaluate their practices to better understand why such complications occur. According to the report, "Identifying which types of patient safety problems exist for different sub-groups of patients is an important first step in developing interventions to reduce disparities and achieve high quality of care for all patients" (Clark, HealthLeaders Media, 6/18).
Covidien (NYSE: COV), a leading global provider of healthcare products, will showcase a number of its most recent innovations in minimally invasive surgery (MIS) and soft tissue repair at the American Society for Metabolic & Bariatric Surgery (ASMBS) annual meeting on June 21-26, 2009, in Grapevine, Texas. These state-of-the-art innovations underscore Covidien"s commitment to working in partnership with the surgical community to develop surgical instruments designed to optimize patient outcomes.
Fresenius Medical Care, which operates the nation"s leading network of dialysis clinics, today endorsed the Performance Excellence and Accountability in Kidney Care (PEAK) campaign recently launched by Kidney Care Partners (KCP) - a coalition of patient advocates, dialysis professionals, care providers and manufacturers working together to improve quality of care for individuals with chronic kidney disease (CKD). The PEAK initiative is designed to significantly reduce the mortality rate for patients in their first year of dialysis.
On the observation of President Obama"s first 150 days in office, AIDS Healthcare Foundation (AHF), the nation"s largest AIDS organization, is continuing its "Change AIDS Obama" campaign with the release of a new online advocacy video chastising the president for his ongoing-and baffling-silence on AIDS.
The emergence of global health initiatives (GHIs), eg, The Global Fund and PEPFAR, has resulted in a striking expansion of key health interventions in recent years, from which millions have benefited. There is also evidence, however, that such initiatives can constrain the health systems of poor countries and that many opportunities to improve efficiency, equity, value for money and outcomes in global public health are still being missed. The health systems strengthening agenda needs more investment, and to be infused with the same sense of ambition and speed that has characterised GHIs. This is one of five key recommendations in a new multi-partner report published in a Health Policy paper in this week"s edition of The Lancet.
Eli Lilly and Company presented data on the short- and long-term efficacy and safety of olanzapine long-acting injection (LAI) in the treatment of adults with schizophrenia or schizoaffective disorder. Olanzapine LAI is an investigational formulation that combines the atypical antipsychotic Zyprexa(R) (olanzapine) with pamoic acid, allowing for the sustained delivery of olanzapine for up to four weeks.
The U.S. Environmental Protection Agency (EPA) plans to switch to a new generation of animal-free tests for predicting the toxicity of chemicals to humans, according to an article scheduled for the June 22 issue of Chemical & Engineering News, ACS" weekly newsmagazine.
Amarillo Biosciences, Inc. (ABI) (OTCBB: AMAR) announced that the screening of volunteers for inclusion in a Phase 2 clinical study of the company"s oral interferon product at the University of Western Australia is now complete. The investigators met their target of screening at least 200 healthy adults for participation in the trial. A total of 215 volunteers were evaluated and 134 of them have been enrolled into the study to date. About 90% of the screened subjects have been found to qualify for the study, so additional enrollments are expected over the next 2 weeks to bring the total number of study participants up to or above the targeted 160 subjects.
Patients with an Implantable Cardioverter Defibrillator (ICD) have an ongoing risk of sudden incapacitation that might cause harm to others while driving a car. Driving restrictions are imposed making these recommendations an important guideline for patients.
With an extensive, inoperable colon cancer and few options available, a Tennessee patient is seeing his cancer steadily regressing on a new outpatient treatment. Individuals from 26 U.S. states and four other countries have been among the first to use NeoPlas Innovation"s new protocol. The Tennessee patient"s early results mirror their successes in battling colon cancer and other very aggressive malignancies.
Self perceived memory impairment is an indicator of pending Alzheimer dementia but not of vascular dementia, according to results of the LADIS (Leukoaraiosis and Disability) study which explores the impact of brain white matter changes on the functioning of independent elderly individuals over a 3 year period. The study is being presented at the current meeting of the European Neurological Society (ENS), a major meeting in European neurology that is gathering more than 2,900 experts from all over the world in Milan.
The Centers for Medicare & Medicaid Services (CMS) issued new guidance for nursing home surveyors, further defining and clarifying several important dimensions of care to help improve nursing home residents" quality of life and environment.
As President Obama prepares to sign a bill giving the Food and Drug Administration (FDA) oversight of the tobacco industry, a new study from Harvard School of Public Health (HSPH) researchers shows that tobacco manufacturers have continually changed the ingredients and the design of their cigarettes over time, even if those changes have exceeded acceptable product variance guidelines. The result, say the researchers, is that consumers who buy the same brand of product are not made aware of how that product has been altered and what effect those alterations might have on their levels of addiction or harm.
Biomodels LLC, a preclinical research organization specializing in cancer support care, announced that its customized research program allowed ActoGeniX NV, a development stage biopharmaceutical company, to rapidly attain Food and Drug Administration (FDA) approval for Phase 1b clinical trials of AGO13 in cancer patients with oral mucositis.
Patricia A. Furlong, Founding President and CEO of Parent Project Muscular Dystrophy (PPMD), the largest non-profit organization in the United States focused on finding a cure for Duchenne muscular dystrophy (Duchenne), announced that PPMD will be honoring United States Senator Johnny Isakson and the American Football Coaches Association (AFCA) with "Change It Champion" awards at the 2009 Connect Conference in Atlanta, Georgia on Saturday, June 27. Other award recipients include Darius Weems and Logan Smalley from the acclaimed documentary "Darius Goes West."
Epeius Biotechnologies stuns the medical and scientific communities with a dramatic demonstration of single-agent efficacy with its lead product, Rexin-G, for metastatic cancer. The landmark article (accessible online as of June 16, 2009 in Molecular Therapy, the Official Journal of The American Society of Gene Therapy, documents the results of two related studies using Rexin-G, a tumor-targeted anti-cancer agent designed to seek-out and destroy metastatic cancers that have spread throughout the body, while sparing normal cells and healthy tissues and organs. Following the FDA"s designation of Rexin-G as an Orphan Drug for the treatment of soft tissue sarcoma and osteosarcoma in 2008, the results of these two independent studies represent a major step toward gaining Accelerated Approval of Rexin-G for osteosarcoma in the United States.
A significant study was released today demonstrating the efficacy of Interactive Patient Care technology on improving outcomes in heart failure care.
Biopure Corporation (Nasdaq: BPUR) announced that the Food and Drug Administration has advised the U.S. Naval Medical Research Center (NMRC) by letter that it may not initiate a clinical trial of Biopure"s oxygen therapeutic Hemopure(R) [hemoglobin glutamer -- 250 (bovine)] under a proposed protocol submitted to the FDA in March 2009. As previously announced, the study, "Restore Effective Survival in Shock" (RESUS) was first proposed and submitted to the FDA in 2005. The proposed trial was placed on clinical hold at that time. It has been resubmitted repeatedly in response to FDA comments and to address comments made by the FDA Blood Products Advisory Committee at an open meeting held in December 2006. Each subsequent submission, including the most recent, was placed on clinical hold.
Last week the FDA knocked the wind out of asthmatics by requesting the manufacturers of Singulair, a popular leukotriene blocking asthma and allergy drug, to upgrade their warning against psychotic side effects. Further respiratory distress was imposed on Zicam users when the FDA also last week announced warnings that the drug may cause a loss of smell.
New research from Washington University School of Medicine in St. Louis has found substantial reductions in binge drinking since the national drinking age was set at 21 two decades ago, with one exception: college students. The rates of binge drinking in male collegians remain unchanged, but the rates in female collegians have increased dramatically.
A new study in CMAJ (Canadian Medical Association Journal) reports that the rates of death and hospital admissions for cardiovascular disease declined thirty percent over a ten year period in Canada. The findings draw attention to successful efforts to prevent heart disease, the leading cause of death globally. But, for the first time, there is indication that more women than men are dying of cardiovascular causes.
Shingles is caused by the herpes varicella-zoster (or simply zoster) virus. This virus also causes chickenpox. Most of us get chickenpox during childhood, but after we recover the virus remains inactive (dormant) in our nervous system. Our immune system stops the virus from becoming active. However, later in life it may become reactivated, causing shingles. Shingles is an infection of a nerve and the area of skin around it.
The results of current clinical trials on new substances for MS therapy are among the new research findings that are being discussed with particular interest at the ENS meeting. Professor Comi is part of an international research team presenting the latest results of a study involving the orally administered drug fingolimod that is still in the clinical trial state and yet to be approved. An earlier study showed that oral fingolimod reduced the annualizied relapse rate in MS patients by more than 50 percent versus placebo.
A new study from the US suggests that the less socially active an older person is, the higher the chances that their motor ability such as strength
House Democrats" health care bill draft released Friday is likely to survive relatively intact, "including a robust new Medicare-like public health plan that would compete with private companies in a national health insurance exchange," Roll Call reports.
A severe lack of evidence is holding doctors back from providing the right treatment for workers suffering from Upper Limb Disorders, according to new research by the NHS Plus funded Occupational Health Clinical Effectiveness Unit (OHCEU) at the Royal College of Physicians. Upper Limb Disorders is an umbrella term for a number of common conditions of the shoulder, arm, wrist and hand, including carpal tunnel syndrome which is estimated to affect around 5% of UK adults
"It"s an exciting time in HIV prevention research. We will see results from a number of critically important HIV prevention research trials this year, as well as see the start of new trials around the world that will yield important answers in the years to come," said Mitchell Warren, AVAC executive director, at the release of AVAC"s 13th annual report of the field.
CNN examines China"s efforts to curb the spread of HIV/AIDS by educating sex workers about the disease and prevention strategies. "It is estimated that some 700,000 people are living with HIV in China and there are about 50,000 new infections every year, according to the Chinese government and UNAIDS. The U.N. agency believes a significant number of those new infections include sex workers," CNN writes.
Instead of responding to natural disasters after they happen, aid should be dedicated to helping countries prepare for future disasters, John Holmes, the U.N."s emergency relief coordinator, said Friday, Reuters reports. "You can"t stop the disasters happening but you can make an enormous difference to whether they kill people and, to some extent at least, have their livelihoods destroyed," Holmes said during a press conference in Geneva that came at the end of a week-long meeting that tackled ideas on how to best prepare poorer countries for natural disasters.
The muscle relaxer Botox has now been shown to positively affect the skin as well.
A collaborative team with members from the Yale Center for Medical Informatics, Yale-New Haven Children"s Hospital/Yale School of Medicine and Acsys Interactive have responded to a national call for proposals from the Robert Wood Johnson Foundation Project HealthDesign:Rethinking the Power and Potential of Personal Health Records, with the design of a trial involving a diverse pediatric population with multiple chronic illnesses. We will be testing whether and how information about patterns of everyday living can be collected and interpreted such that patients can take action to better manage their health and clinicians can integrate new insights into clinical care processes. It is envisioned that leading edge technology such as the Google Health PHR platform along with Apple"s iPhone or iTouch mobile devices will be used to capture the ODLs. The proposed project team includes specialists experienced in these approaches and ethnographic evaluation; in pediatric disease management; in patient-centered care involving patient-clinician-technology partnerships; in bioethics; and in IT technical development.
Now there"s a new reason for the weight-conscious to drink fat free milk at breakfast time, suggests a new study published in the July issue of the American Journal of Clinical Nutrition. Researchers in Australia found that drinking fat free milk in the morning helped increase satiety, or a feeling of fullness, and led to decreased calorie intake at the next meal, as compared with a fruit drink. The milk drinkers ate about 50 fewer calories (or nearly 9% less food) at lunch.
Scientists in China are recommending that the Chinese government consider phasing out the direct burning of traditional chunks of coal in millions of households. It suggests that the government substitute coal briquettes and improved stoves for cooking and heating to help reduce the country"s high air pollution levels. The recommendation stems from one of the first scientific studies showing that this approach is effective in improving air quality, including a 98 percent reduction in air pollution from tiny, inhalable particles of coal soot. Their study is scheduled for the July 15 issue of ACS" Environmental Science & Technology, a semi-monthly journal.
The overall aim of National Falls Awareness Day, held on the 23rd June 2009 is to raise awareness of the increased risk of falling as people age. Many of the products in Mountway"s current extensive portfolio of independent living solutions can be used to aid with falls prevention.
With millions of people in the United States eagerly awaiting those July 4 fireworks displays - and our Canadian neighbors doing likewise for their July 1 Canada Day celebrations - here"s a prospect for those light shows of the future likely to ignite a smile on Mother Nature"s face: A new generation of "green" fireworks is quietly making its way toward the sky.
A study published in the July issue of Anesthesiology offers perhaps the first estimation of how genomic copy number variation (CNV) can influence anesthetic sensitivity and the magnitude of this influence.
Researchers at the University of Illinois report that a toxic molecule known to damage cells and cause disease may also play a pivotal role in bird migration. The molecule, superoxide, is proposed as a key player in the mysterious process that allows birds to "see" Earth"s magnetic field.
Physiological and biochemical changes that occur during fasting in Ramadan are not a risk factor for stroke and do not affect the short-term survival of patients. This is the result of a study by a team of researchers from the Isfahan University of Medical Sicences (Iran). The data are being presented at the annual meeting of the European Neurological Society in Milan (Italy).
A good partner relationship can act as a buffer for those exposed to work-related stress.
We humans prefer to be addressed in our right ear and are more likely to perform a task when we receive the request in our right ear rather than our left. In a series of three studies, looking at ear preference in communication between humans, Dr. Luca Tommasi and Daniele Marzoli from the University "Gabriele d"Annunzio" in Chieti, Italy, show that a natural side bias, depending on hemispheric asymmetry in the brain, manifests itself in everyday human behavior. Their findings were just published online in Springer"s journal Naturwissenschaften.
A group of German investigators demonstrated that the early increase in phosphorylated CREB (pCREB) is related to treatment response and does not depend on pharmacological interventions or brain-derived neurotrophic factor (BDNF) plasma levels. For the first time, cellular biological markers could be associated with response to psychotherapy.
According to the World Health Organization (WHO), age-related macular degeneration (AMD) ranks third as a cause of visual impairment. It is the primary cause of visual impairment in industrial countries with a blindness prevalence of 8.7 percent. A new medical study indicates, however, that with the use of the Macular Health vitamin supplement there is a way to preserve the vision of millions of aging adults suffering from AMD.
The Employment Policies Institute (EPI) released a new study which shows that the widely employed estimate of 47 million uninsured Americans is a misleading representation of the problem. The study, authored by Drs. June and David O"Neill of Baruch College and City University of New York, shows that more than 43 percent, or 18 million, of uninsured Americans ages 18-64 could likely afford health coverage and are actually "voluntarily uninsured." June O"Neill served as Director of the Congressional Budget Office (CBO) from 1995-1999.
The American Cancer Society and the National Palliative Care Research Center (NPCRC) are awarding $1.5 million in research grants to researchers at eleven institutions for studies aimed at reducing suffering for seriously ill patients and their family caregivers. The studies will be conducted over the next two years. The NPCRC, in collaboration with the American Cancer Society, has directed over $5 million towards supporting 38 palliative care research projects since starting this initiative three years ago.
Depression in older adults too often goes unrecognized and untreated, resulting in untold misery, worsening of medical illness, and early death. A new study has identified one important remedy: Adding a trained depression care manager to primary care practices can increase the number of patients receiving treatment, lead to a higher remission rate of depression, and reduce suicidal thoughts.
Emergency physicians who evaluate patients with non-specific chest pain using whole chest multi-detector CT (MDCT) combined with retrospective electrocardiogram (ECG) gating can reduce the patient radiation dose by 71% using MDCT combined with prospective ECG triggering instead, according to a study performed at the University of Washington School of Medicine, Seattle, WA. Prospective ECG triggering enables the CT scanner to monitor the ECG signal of several heart beats in real time and turns the radiation beam on only during alternate beats; retrospective ECG gating also monitors the ECG signal of heartbeats but turns the radiation beam on throughout several consecutive beats, thus delivering more radiation.
Researchers at The University of Texas School of Public Health have developed a game for HIV-positive youth, +CLICK, designed to reduce secondary transmission of the virus.
Australian regenerative medicine company Mesoblast Limited has announced successful results from the first five patients who underwent bone marrow transplantation with haematopoietic stem and progenitor cells expanded by the patented allogeneic, or "off-the-shelf", Mesenchymal Precursor Cells (MPCs).
The Maine Center for Disease Control and Prevention of the Maine Department of Health and Human Services, is issuing an advisory about the danger of carbon monoxide poisoning when people open camps for the summer.
The Minnesota Department of Health (MDH) will offer free mammograms through a televised phone bank on FOX 9 KMSP-TV in Minneapolis on Thursday, June 25, 2009. The phone bank will air during the 5 p.m., 5:30 p.m., 9 p.m. and 10 p.m. newscasts. The mammograms are offered through the Sage Screening Program, a state and federally funded program that provides free breast and cervical cancer screenings to uninsured and underinsured women age 40 and older. Newly enrolled women in the program will also receive $20 for being screened, which has been shown to increase screening rates.
The pharmaceutical company, Merck, announced Monday it was partnering with the non-profit Drugs for Neglected Diseases initiative (DNDi) in an effort to improve treatments for neglected tropical diseases (NTD), the AP/CNBC reports. "The agreement covers drug candidates for illnesses like visceral leishmaniasis and Chagas disease, potentially lethal parasitic illnesses spread by insects. Current treatment for those illnesses may be toxic, or very expensive, or difficult to administer, Merck said," AP/CNBC writes (AP/CNBC, 6/22).
Treating someone with an intellectual disability can be challenging for general
The Allied Health Professions Leadership Challenge winners are East Midlands SHA, The Department of Health announced today.
Men blame male victims of rape for not fighting off their attacker. This is one of the findings of Dr Michelle Davies and Dr Paul Rogers from University of Central Lancashire who will present their research at the British Psychological Society"s Division of Forensic Psychology Annual Conference today, Wednesday 24th June 2009. The conference is being held the University of Central Lancashire, Preston.
New research indicates that a finding on a routine electrocardiogram that signals a disorder of the electrical conducting system in one part of the heart and previously believed to be benign is associated with an increased risk for atrial fibrillation, the implantation of a pacemaker or death, according to a study in the June 24 issue of JAMA.
A common electrocardiogram (ECG) finding that has largely been considered insignificant may actually signal an increased risk of atrial fibrillation (a chronic heart rhythm disturbance), the future need for a permanent pacemaker and an increased risk for premature death. In their report in the June 24 Journal of the American Medical Association, researchers from Massachusetts General Hospital (MGH) and Boston University School of Medicine describe results of the first large-scale study looking at the significance of a prolonged PR interval in a general population.
On June 18, the Canada Foundation for Innovation (CFI) announced the award of $9.16 million for the creation of a national technology platform aimed at mapping the human interactome. This national platform, headed by Dr. Benoit Coulombe from the Institut de recherches cliniques de Montrç©al (IRCM), will not only provide Canadian researchers with new state-of-the-art equipment in proteomics, functional genomics and bioinformatics, but also bring together integrated infrastructure for deciphering the human interactome an expertise that, until now, has been spread in 12 universities across Canada.
FIRMAGON® (degarelix) a new fast-acting hormone treatment for advanced prostate cancer is being offically launched in the UK yesterday at the British Association of Urological Surgeons Annual Meeting in Glasgow.
Approximately 5 million adults age 19 to 23 in the United States had no health insurance in 2006 for the entire year and 30 percent of them said they didn"t think it was worth the cost, according to the latest News and Numbers from the Agency for Healthcare Research and Quality.
Novavax, Inc. (Nasdaq: NVAX) announced publication of the preclinical study results that supported the clinical development of the company"s investigational VLP vaccine against the H3N2, H1N1 and B influenza strains. The study, which was conducted by scientists from the University of Pittsburgh, Center for Vaccine Research and Novavax, was published in the June 24, 2009 online issue of PLoS ONE. The vaccine contains three VLPs mixed together in a single formulation; each made up of the hemagglutinin (HA), neuraminidase (NA) and matrix 1 (M1) proteins from the representative strains. These proteins are important for broad protection against influenza, which is responsible for nearly 200,000 hospitalizations and 36,000 deaths in the U.S. each year. The vaccine is currently in Phase 2 clinical testing.
In the recently completed 12 week Phase IIb clinical trial in 494 patients with type 2 diabetes mellitus (T2DM), "Melogliptin", Glenmark"s investigational medicine from a new class of diabetes treatments called dipeptidyl peptidase 4 (DPP-4) inhibitors, improved glycemic control in patients with type 2 diabetes mellitus and exhibited excellent safety and tolerability profile. In addition, patients taking Melogliptin experienced low incidence of hypoglycemia and neutral effect on body weight.
According to the American Diabetes Association, nearly 24 million people have diabetes. Of that number, unfortunately, 5.7 million people are unaware that they have the disease. Diabetes can affect multiple parts of the body, including the kidneys, nerves, heart and even the mouth.
Women who have migraines with aura may be more likely to have a stroke or heart attack than women who don"t have the condition, and the association varies by migraine frequency, according to research published in the June 24, 2009, online issue of Neurology®, the medical journal of the American Academy of Neurology. An aura is a visual or other sensory disturbance that occurs before the migraine starts, such as seeing bright lights.
From the west to east coast, Americans are experiencing record-breaking temperatures. Some states are reporting triple-digit numbers and the heat has been the cause of several reported deaths. "Children and the elderly are considered the most vulnerable population. It is harder for their bodies to respond to these high temperatures," said Richard N. Bradley, M.D., associate professor of emergency medicine and chief of EMS and disaster medicine at The University of Texas Medical School at Houston.
Phase Forward (NASDAQ: PFWD), a leading provider of data management solutions for clinical trials and drug safety, announced the availability of Empirica™ Study, formerly the Clinical Trials Signal Detection product (CTSD™). The Empirica Study solution helps clinical and safety teams improve their understanding of a product"s emerging safety profile during clinical development by facilitating the timely detection, review and analysis of safety issues in clinical trials data.
Scientists in the US have discovered that cancer tumors that don"t spread to other parts of the body secrete a protein called prosaposin and that
Compugen Ltd. (NASDAQ:CGEN) announced that CGEN-25007, a novel peptide antagonist of gp96 with potent anti-inflammatory activity, has shown positive therapeutic effects in an animal model of inflammatory bowel disease (IBD), a commonly used term covering ulcerative colitis and Crohn"s disease.
AARP President Jennie Chin Hansen is
"A majority of Americans see government action as critical to controlling runaway health-care costs, but there is broad public anxiety about the potential impact of reform legislation and conflicting views about the types of fixes being proposed on Capitol Hill, according to a new Washington Post-ABC News poll," The Washington Post reports. "Most respondents are "very concerned" that health-care reform would lead to higher costs, lower quality, fewer choices, a bigger deficit, diminished insurance coverage and more government bureaucracy. About six in 10 are at least somewhat worried about all of these factors, underscoring the challenges for lawmakers as they attempt to restructure the nation"s $2.3 trillion health-care system." Many respondents are "nervous about future changes" because of a "fear they may lose what they currently have. "More than eight in 10 said they are satisfied with the quality of care they now receive and relatively content with their own current expenses." In his news conference Tuesday, President Barack Obama "sought to leverage that apprehension" by noting that "premiums have been doubling every nine years, going up three times faster than wages."
Figures from the British Institute for Anger Management reveal that the UK already has the worst road rage figures of any European nation, with 80% of drivers saying they"ve been involved in an incident and 1 in 4 admitting to committing an act of road rage themselves. Men are three times more likely to commit an act of aggression than women and over 60% of drivers say they have been intimidated by aggressive tailgating.
Medicaid providers in California won a legal challenge over program cuts in the case "Maxwell-Jolly v. Independent Living Center of Southern California." McKnight"s Long Term Care News reports that "The U.S. Supreme Court has let stand a federal appeals court ruling that says California"s Medicaid providers have a right to challenge state cuts to Medi-Cal provider fees. Victor Norma Jean Vescovo, the executive director of the Independent Living Center of Southern California, says the ruling will make it easier to ensure state Medicaid (known in the state as Medi-Cal) cuts will be made for needs-based reasons, not just economic reasons, the Bureau of National Affairs reported.
Local campaigners met with MPs and senior primary care trust staff at a parliamentary event today to raise awareness of HIV and discuss ways to increase HIV testing.
Oprah Winfrey "has scored good ratings with her health episodes" of her television show, but "in doing so, she seems to have thrown therapeutic caution to the wind," such as on her shows featuring actress Suzanne Somers" opinions on bioidentical hormone replacement therapy, Salon contributor and physician Rahul Parikh writes in an opinion piece. Somers, while advocating for the use of bioidentical HRT as a safe alternative to traditional HRT for postmenopausal women, said she used "mega-doses of bioidenticals continuously and aggressively," according to Parikh. Parikh writes that Somers, on television and in her 2007 book, "argues that these hormones are more natural, more effective and safer than what doctors prescribe." According to Parikh, "In reality, ...÷ there are no good medical studies to back up those claims."Parikh says that although "what Somers was advocating was radically different from standards of medical care," Winfrey "was not concerned" and even said that Somers ""might be a pioneer,"" Parikh continues. Winfrey billed the episode as part of a ""great debate"" on hormone therapy, but she "didn"t ask about whether [Somers"] super-hormone regimen could have contributed to Somers" history of breast cancer"; "her hysterectomy, the result of pre-cancerous changes in her uterus from her use of HRT"; or the "validity of Somers" book"s s, many of whom are neither experts in women"s health or endocrinology, nor board-certified physicians, nor experienced researchers," Parikh states. He adds, "It"s not that Winfrey doesn"t try to maintain medical credibility in her shows," but "her efforts seem subpar," noting that her show "reaches millions of people, while each doctor can reach only one patient at a time." Parikh concludes, "That could easily be corrected by Winfrey providing more thought and balance in her medical advice" (Parikh, Salon, 5/15).
A new study suggests that a drop in colorectal cancer incidence seen nationwide has not occurred among people living in poorer communities, and suggests that barriers to health care may be to blame. The study appears online in the journal Cancer Causes and Control.
The National Association of Chain Drug Stores (NACDS) today announced that the 2009 NACDS Pharmacy & Technology Conference will provide a forum at which to provide further recognition to Leonard J. DeMino, RPh., a chain pharmacy icon whose resume already includes some of the industry"s highest honors and achievements. This news comes as DeMino announces his retirement as senior pharmacy consultant to NACDS, effective in June 2009.
Psychopaths are more likely to use violence in a cold blooded, calculated way than non-psychopathic violent offenders.
New research1 conducted by Asthma UK suggests that people with asthma are struggling to afford the medicines they need to stay well and out of hospital, and that this situation has been made even worse since the recession began.
Mitochondria are the powerhouses of cells. Underneath their smooth surface they harbor an elaborately folded inner membrane. It holds a multitude of bottleneck like invaginations, which expand into elongated cavities (cristae). The narrow shape of the entrance or pore to the cristae ("crista junction") allows separation of the intracristal space and storage of molecules. Cytochrome c, for example, an important signaling protein in programmed cell death (apoptosis), is stored in this compartment. When apoptosis is triggered, the pores enlarge and cytochrome c is released into the cytosol. Thus, understanding of how the pore diameter and the shape of the inner membrane are regulated on a molecular basis is of great relevance to a better understanding of mitochondrial function in general. Recently, in cooperation with other research teams, the group of Prof. Andreas Reichert, who has been appointed as professor for Mitochondrial Biology to the Goethe University within the Cluster of Excellence Macromolecular Complexes in 2007, has identified two proteins linked in an antagonistic manner that are relevant for governing inner membrane structure.
Current research suggests that levels of gastrin play a key role in the development of Helicobacter-induced stomach cancer. The related report by Takaishi et al, "Gastrin is an essential cofactor for Helicobacter-associated gastric corpus carcinogenesis in C57BL/6 mice," appears in the July 2009 issue of The American Journal of Pathology.
Scientists have uncovered a novel mechanism linking soluble amyloid í² protein with the synaptic injury and memory loss associated with Alzheimer"s disease (AD). The research, published by Cell Press in the June 25 issue of the journal Neuron, provides critical new insight into disease pathogenesis and reveals signaling molecules that may serve as potential additional therapeutic targets for AD.
Frankenman International Ltd, the manufacturer and supplier of surgical instruments, announced that its entire CHEX™ range of surgical staplers had been granted FDA approval. This development complements the CE and ISO accreditation it has already acquired. FDA approval endorses Frankenman"s commitment to total quality in surgical stapling and wound closure devices, and further validates its position as a trusted alternative supplier in these markets.
A multi-center clinical trial led by a Riley Hospital for Children endocrinologist has found that inhaled growth hormone (GH) is well tolerated by children with GH deficiency and that this easy-to-use method can, over a one-week period, safely deliver GH to the blood stream. In addition to having implications for those who need GH, this first pediatric study of administering it through the lungs may also help researchers interested in using this convenient method for effectively delivering other types of medications to children.
A variation in a gene that is active in the central nervous system is associated with increased risk for obesity, according to an international study in which Albert Einstein College of Medicine of Yeshiva University played a major role. The research adds to evidence that genes influence appetite and that the brain plays a key role in obesity.
A protein called STAT3 has been found to play a fundamental role in converting normal cells to cancerous cells, according to a new study led by David E. Levy, Ph.D., professor of pathology and microbiology at NYU Langone Medical Center. The study, published in the June 26th issue of the journal Science, found that STAT3, in addition to its role in the cell nucleus regulating gene expression, is also present in mitochondria and regulates the activity of the electron transport chain in tumors cells. Mitochondria are the basic energy-producing organelles of the cell and are known to be critical for tumor cell metabolism.